Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "

NCT01075061 | Completed

• 2 other identifiers: C09-062009-A00490-57
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.

Conditions

Healthy

Keywords

Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene

Outcome Measures

Primary Outcomes (1)

• - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM

  08/2011

Secondary Outcomes (1)

• - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis

  08/2011

Study Arms (3)

healthy volunteers

OTHER

healthy volunteers

Other: healthy volunteers

Kallmann

OTHER

Kallmann syndrome patients

Other: Kallmann

Congenital Mirror Movement

OTHER

patients with CMM

Other: Congenital Mirror Movement

Interventions

healthy volunteers OTHER

morphological and functional brain MRI; transcranial magnetic stimulation

healthy volunteers

Kallmann OTHER

morphological and functional brain MRI; transcranial magnetic stimulation

Kallmann

Congenital Mirror Movement OTHER

morphological and functional brain MRI; transcranial magnetic stimulation

Congenital Mirror Movement

Eligibility Criteria

• Age: 11 Years - 82 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged from 11 to 82 years
• Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
• No contraindication for MRI or TMS study

You may not qualify if:

• inability to provide an informed consent
• Simultaneous participation in another clinical trial
• Treatment that modulate cortical excitability (for the TMS part of the study only)

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière

Paris, 75013, France

Location

Related Publications (1)

• Depienne C, Cincotta M, Billot S, Bouteiller D, Groppa S, Brochard V, Flamand C, Hubsch C, Meunier S, Giovannelli F, Klebe S, Corvol JC, Vidailhet M, Brice A, Roze E. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology. 2011 Jan 18;76(3):260-4. doi: 10.1212/WNL.0b013e318207b1e0.

  PMID: 21242494 BACKGROUND

Study Officials

• Emmanuel ROZE, MD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 4, 2010
• First Posted: February 24, 2010
• Study Start: February 1, 2010
• Primary Completion: July 1, 2011
• Study Completion: July 1, 2011
• Last Updated: August 27, 2025

Record last verified: 2016-02

Locations

FR (1)