Transcranial Doppler Ultrasonography and Brain Death

NCT01070563 | Completed

• 1 other identifier: IAAM 2010-1
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

In France the diagnosis of brain death relies on electroencephalography (EEG) or cerebral angiography. Concerning the latter a time of 6 hours is mandatory between the clinical diagnosis and the realization of the cerebral computed tomography (CT) angiography. Transcranial doppler (TCD) is not recommended in the french guidelines for the diagnosis of brain death. In other countries, some flow patterns allow to confirm the diagnosis of brain death. The hypothesis of our study is that TCD could shorten the time between the clinical diagnosis of brain death and the realization of the CT angiography.

Conditions

Brain Dead

Keywords

Brain death; CT angiography; Ultrasonography, doppler, transcranial

Outcome Measures

Primary Outcomes (1)

• Time between clinical diagnosis of brain death and realization of CT angiography

  the outcome is assessed when the CT angiography is performed

Secondary Outcomes (1)

• Number of CT angiography required for the diagnosis of brain death

  the outcome is measured until the diagnosis of brain death is confirmed

Study Arms (2)

Usual

CT angiography is performed 6 hours after the clinical diagnosis of brain death.

TCD

When the diagnosis of brain death is made, TCD is performed and then every 2 hours until the flow patterns compatible with brain death are found. Then a CT angiography is performed.

Other: Transcranial doppler

Interventions

Transcranial doppler OTHER

A TCD is performed on all cerebral arteries (mean cerebral arteries, anterior cerebral arteries, basilar trunk, vertebral arteries and carotid arteries) until a flow pattern compatible with brain death is found

TCD

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ICU patients showing brain injury due to stroke or trauma and developping subsequently brain death

You may qualify if:

• brain death patients

You may not qualify if:

• craniectomy
• post anoxia encephalopathy
• no TCD performed before the clinical diagnosis of brain death
• transtemporal approach impossible

Sponsors & Collaborators

• Institut d'Anesthesiologie des Alpes Maritimes: lead

Study Sites (1)

Centre Hospitalier Universitaire de Nice

Nice, 06000, France

Location

Related Publications (1)

• Orban JC, El-Mahjoub A, Rami L, Jambou P, Ichai C. Transcranial Doppler shortens the time between clinical brain death and angiographic confirmation: a randomized trial. Transplantation. 2012 Sep 27;94(6):585-8. doi: 10.1097/TP.0b013e3182612947.

  PMID: 22918218 DERIVED

MeSH Terms

Conditions

Brain Death

Interventions

Ultrasonography, Doppler, Transcranial

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Coma; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Echoencephalography; Neuroradiography; Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Radiography; Ultrasonography; Ultrasonography, Doppler; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• Jean-Christophe Orban, MD

  Nice University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 12, 2010
• First Posted: February 18, 2010
• Study Start: February 1, 2009
• Primary Completion: June 1, 2011
• Study Completion: June 1, 2011
• Last Updated: July 4, 2011

Record last verified: 2011-06

Locations

FR (1)