The Use of Non-invasive Multidetector Coronary Computed Tomography Imaging for the Assessment of Coronary Calcification in Persons With Spinal Cord Injury
Sponsor study identifier
observational
150
1 country
1
Study Start
February 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2011
Actual (reported)Study Completion
February 2012
Actual (reported)Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD has not been performed prospectively in those with SCI. CHD is a leading cause of death in spinal cord injury, occurring at younger ages than in the able-bodied population. Conventional risk factors for CHD are high serum concentrations of low-density lipoprotein (LDL), low serum concentrations of high-density lipoprotein (HDL), diabetes mellitus (DM), positive smoking history, and positive family history of premature CHD. Coronary calcification (CAC) is a commonly occurring phenomenon that does not necessarily indicate significant obstructive disease. Studies have shown that a strong association exists between coronary calcification and coronary heart disease. The purpose of this study is to compare the CAC scores in persons with SCI with a historical control group of able-bodied persons from a national data base who will be matched for conventional risk factors for coronary artery disease (CAD) and to determine the relationship between CAC scores and conventional and emerging risk factors for CAD.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2012
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2010
Date type not reportedThis date has not been verified as actual or estimated.
February 8, 2010
Actual (reported)February 9, 2010
Actual (reported)October 2011
Actual (reported)February 2012
Actual (reported)Quantification of coronary calcium
2 years
Determine the relationship between calcification scores and vascular reactivity
2 years
SCI subjects will be included in the study if they have moderate or high risk for coronary heart disease, who have participated in a previous screening study.
VA Medical Center, Bronx
The Bronx, New York, 10468, United States
William Bauman, MD
VA Medical Center, Bronx
First Submitted
February 8, 2010
First Posted
February 9, 2010
Study Start
February 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2011
Actual (reported)Iron & Vitamin C Study
Contact the study team to confirm eligibility.
Study Completion
February 2012
Actual (reported)Last Updated
October 3, 2012
Record last verified: 2012-10
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Source: ClinicalTrials.gov.
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