Copeptin in Differentiation of Polyuria and Polydipsia

NCT01056887 | Completed DMC

• 2 other identifiers: 1712197933/07
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy. Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease, because both groups are associated with similar urinary osmolalities. The determination of plasma arginine vasopressin is unusual in this context, since measurement of AVP is not reliably. C-terminal ProVasopressin (copeptin) is secreted stoichiometrically with AVP from the neurohypophysis, but has a longer half life in the circulation, and is thus easier to measure. Therefore, the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia.

Conditions

Polyuria; Polydipsia

Keywords

diabetes insipidus; primary polydipsia; copeptin; Utility of plasma copeptin in differential diagnosis of polyuria/ polydipsia while performing a traditional deprivation test

Study Arms (1)

Primary Polydip, D. insipidus

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy probands Patients with diabetes insipdus centralis totalis/ partials Patients with diabetes insipidus renalis Patients with primary polydipsia

You may qualify if:

• Patients with polydipsia/ polyuria, with indication for performing a deprivation test
• \> 18 years

You may not qualify if:

• dDAVP during the last 14d
• pregnancy

Sponsors & Collaborators

• University of Wuerzburg: lead
• Dr. Carson Liu Med Corp.: collaborator

Study Sites (1)

Univ Hospital Wuerzburg

Würzburg, Bavaria, 97080, Germany

Location

Related Publications (1)

• Fenske W, Quinkler M, Lorenz D, Zopf K, Haagen U, Papassotiriou J, Pfeiffer AF, Fassnacht M, Stork S, Allolio B. Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests. J Clin Endocrinol Metab. 2011 May;96(5):1506-15. doi: 10.1210/jc.2010-2345. Epub 2011 Mar 2.

  PMID: 21367924 DERIVED

MeSH Terms

Conditions

Polyuria; Polydipsia; Diabetes Insipidus; Polydipsia, Psychogenic

Condition Hierarchy (Ancestors)

Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Kidney Diseases; Pituitary Diseases; Endocrine System Diseases; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 25, 2010
• First Posted: January 26, 2010
• Study Start: March 1, 2008
• Primary Completion: November 1, 2010
• Study Completion: November 1, 2010
• Last Updated: April 25, 2011

Record last verified: 2010-11

Locations

DE (1)