Analysis of Clinical Outcomes in Patients Undergoing Acute Dialysis Therapy at Intensive Care Units

NCT01039753 | Unknown

• 1 other identifier: 200912015R
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury is more frequent and the mortality rate would be as high as 50-60% when the renal replacement therapy was needed. Many studies about the timing of start and discontinuation of dialysis, dialysis dose, dialyzer, anticoagulation and dialysates were initiated but the results were still controversial. In addition, more new biomarkers were found to predict the outcome of acute kidney injury and these biomarkers may play an important role for the dilemma of aforementioned studies. This observational prospective study has two objectives:

1. 1.To find the predictors of outcome for the acute kidney injury with renal replacement therapy and determine the appropriate method.
2. 2.To find the relationship between new biomarkers and acute kidney injury and determine whether it can be a factor for the monitor of the response of the renal replacement therapy.

Conditions

Acute Kidney Injury

Keywords

acute kidney injury; renal replacement therapy; biomarkers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients older than 18 years-old and admitted to intensive care units of National Taiwan University Hospital

You may qualify if:

• Patients older than 18 years-old and admitted to intensive care units of National Taiwan University Hospital

You may not qualify if:

• End stage renal disease
• Terminal disease with estimated life span shorter than 28 days

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 10002, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Collect serum and urine sample for biomarkers at the following timing: start date of renal replacement therapy, discontinuation date of renal replacement therapy, 7 days after discontinuation date of renal replacement therapy. 10ml blood and 10ml urine will be collected at each sampling

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Yung-Ming Chen, Ph.D

CONTACT

886-23123456; chenym@ntuh.gov.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 24, 2009
• First Posted: December 25, 2009
• Study Start: January 1, 2010
• Primary Completion: June 1, 2011
• Study Completion: July 1, 2011
• Last Updated: January 29, 2010

Record last verified: 2010-01

Locations

TW (1)