Mindfulness Based Cognitive Therapy for Recurrent Depression

NCT01038765 | Completed Results

• 2 other identifiers: MFN-2005-20102005 6028
• Study Type: interventional
• Target: 220
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effectiveness and possible mediating factors of Mindfulness Based Cognitive Therapy (MBCT) for recurrent depression.

Conditions

Depressive Disorder, Major

Keywords

Recurrent Major Depressive Disorder; Mindfulness Based Cognitive Therapy; Randomized Controlled Trial

Outcome Measures

Primary Outcomes (1)

• Depressive Symptoms

  Hamilton Depression Rating Scale. The HAMD is a standardized 17-item interview to measure number and severity of depressive symptoms on a 0-52 score. Higher values indicate a worse outcome. Specifical, HAMD scores can be interpreted as "no depression" (0-7), "mild depression" (8-16), "moderate depression" (17-23) and "severe depression" (24-52).

  Assessments were performed at 0, 3, 6, 9, 12, 15 months, and change between 3 and 0 months was the primary analysis.

Secondary Outcomes (1)

• Self-report Depressive Symptoms

  Assessments were performed at 0, 3, 6, 9, 12, 15 months, and change between 3 and 0 months was the primary analysis

Study Arms (2)

Mindfulness Based Cognitive Therapy

EXPERIMENTAL

Mindfulness Based Cognitive Therapy

Behavioral: Mindfulness Based Cognitive Therapy

Waiting list control group

NO INTERVENTION

3-month waiting list group

Interventions

Mindfulness Based Cognitive Therapy BEHAVIORAL

8-weeks group based intervention of mindfulness and cognitive behavioural techniques

Also known as: MBCT

Mindfulness Based Cognitive Therapy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• or more previous depressive episodes
• if treated with medication: constant dose of at least 6 weeks

You may not qualify if:

• Bipolar Disorder
• Psychotic disorder
• Neurological or somatic illness affecting depression or outcome measures
• Current alcohol or drugs dependency
• Acute need of psychiatric treatment

Sponsors & Collaborators

• Radboud University Medical Center: lead
• Fonds Psychische Gezondheid: collaborator

Study Sites (1)

Radboud University Nijmegen Medical Center

Nijmegen, Gelderland, 6525 GC, Netherlands

Location

Related Publications (6)

• Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000 Aug;68(4):615-23. doi: 10.1037//0022-006x.68.4.615.

  PMID: 10965637 BACKGROUND

• Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol. 2004 Feb;72(1):31-40. doi: 10.1037/0022-006X.72.1.31.

  PMID: 14756612 BACKGROUND

• Barnhofer T, Crane C, Hargus E, Amarasinghe M, Winder R, Williams JM. Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study. Behav Res Ther. 2009 May;47(5):366-73. doi: 10.1016/j.brat.2009.01.019. Epub 2009 Feb 5.

  PMID: 19249017 BACKGROUND

• Kenny MA, Williams JM. Treatment-resistant depressed patients show a good response to Mindfulness-based Cognitive Therapy. Behav Res Ther. 2007 Mar;45(3):617-25. doi: 10.1016/j.brat.2006.04.008. Epub 2006 Jun 23.

  PMID: 16797486 BACKGROUND

• Kingston T, Dooley B, Bates A, Lawlor E, Malone K. Mindfulness-based cognitive therapy for residual depressive symptoms. Psychol Psychother. 2007 Jun;80(Pt 2):193-203. doi: 10.1348/147608306X116016.

  PMID: 17535594 BACKGROUND

• van Aalderen JR, Donders AR, Giommi F, Spinhoven P, Barendregt HP, Speckens AE. The efficacy of mindfulness-based cognitive therapy in recurrent depressed patients with and without a current depressive episode: a randomized controlled trial. Psychol Med. 2012 May;42(5):989-1001. doi: 10.1017/S0033291711002054. Epub 2011 Oct 3.

  PMID: 22017808 DERIVED

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

Mindfulness-Based Cognitive Therapy

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Mindfulness; Cognitive Behavioral Therapy; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Results Point of Contact

• Title: Anne E.M. Speckens
• Organization: Radboud University Medical Centre

a.speckens@psy.umcn.nl

0031243610449

Study Officials

• Anne EM Speckens, Prof. dr.

  Radboud University Medical Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anne E.M. Speckens, Prof. dr.

Study Record Dates

• First Submitted: December 22, 2009
• First Posted: December 24, 2009
• Study Start: January 1, 2005
• Primary Completion: March 1, 2010
• Study Completion: January 1, 2011
• Last Updated: January 30, 2024
• Results First Posted: January 30, 2024

Record last verified: 2024-01

Locations

NL (1)