Omega-3 Fatty Acids and Health Effects

NCT01034423 | Completed

• 1 other identifier: 6.2008.2215
• Study Type: interventional
• Target: 69
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators want to study health effects from omega-3 fatty acids, from fishoil with different quality.

Conditions

Healthy

Keywords

Focus: health effects from omega-3 fatty acids, from fish oil with different quality

Outcome Measures

Primary Outcomes (1)

• Primary and secondary oxidation products

  baseline (0 weeks), 3 weeks and 7 weeks

Secondary Outcomes (1)

• inflammatory markers

  after 0,3 and 7 weeks

Study Arms (3)

omega-3 high quality

EXPERIMENTAL

Dietary Supplement: Omega-3; Dietary Supplement: sun flower oil

omega-3 low quality

EXPERIMENTAL

Dietary Supplement: Omega-3; Dietary Supplement: sun flower oil

placebo

PLACEBO COMPARATOR

Dietary Supplement: Omega-3; Dietary Supplement: sun flower oil

Interventions

Omega-3 DIETARY_SUPPLEMENT

Capsules with omega-3 fatty acids.

omega-3 high quality; omega-3 low quality; placebo

sun flower oil DIETARY_SUPPLEMENT

Capsules with sun flower oil.

omega-3 high quality; omega-3 low quality; placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals.

You may not qualify if:

• Pregnant women, lactating women, chronic diseases and smoking.

Sponsors & Collaborators

• Oslo Metropolitan University: lead

Related Publications (4)

• Myhrstad MC, Ottestad I, Gunther CC, Ryeng E, Holden M, Nilsson A, Bronner KW, Kohler A, Borge GI, Holven KB, Ulven SM. The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects. Genes Nutr. 2016 May 31;11:16. doi: 10.1186/s12263-016-0530-6. eCollection 2016.

  PMID: 27551317 DERIVED

• Myhrstad MC, Ulven SM, Gunther CC, Ottestad I, Holden M, Ryeng E, Borge GI, Kohler A, Bronner KW, Thoresen M, Holven KB. Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach. J Intern Med. 2014 Nov;276(5):498-511. doi: 10.1111/joim.12217. Epub 2014 Mar 20.

  PMID: 24641624 DERIVED

• Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyotylainen T, Oresic M, Bronner KW, Holven KB, Ulven SM, Myhrstad MC. Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS One. 2012;7(8):e42550. doi: 10.1371/journal.pone.0042550. Epub 2012 Aug 28.

  PMID: 22952598 DERIVED

• Ottestad I, Vogt G, Retterstol K, Myhrstad MC, Haugen JE, Nilsson A, Ravn-Haren G, Nordvi B, Bronner KW, Andersen LF, Holven KB, Ulven SM. Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial. Br J Nutr. 2012 Jul;108(2):315-26. doi: 10.1017/S0007114511005484. Epub 2011 Dec 5.

  PMID: 22136711 DERIVED

MeSH Terms

Interventions

Docosahexaenoic Acids

Intervention Hierarchy (Ancestors)

Fatty Acids, Omega-3; Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fatty Acids, Unsaturated; Fatty Acids; Fish Oils; Oils

Study Officials

• Stine M Ulven, PhD

  Oslo Metropolitan University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 16, 2009
• First Posted: December 17, 2009
• Study Start: September 1, 2009
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2009
• Last Updated: February 4, 2015

Record last verified: 2015-02