NCT01033669

Brief Summary

Assessment of the inhalation profiles of four dry powder inhalers in patients with variable degrees of lung obstruction

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
57

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2009

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 24, 2009

Completed
1 month until next milestone

Study Start

First participant enrolled

November 1, 2009

Completed
2 months until next milestone

First Posted

Study publicly available on registry

December 16, 2009

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2010

Completed
Last Updated

March 17, 2010

Status Verified

March 1, 2010

Enrollment Period

3 months

First QC Date

September 24, 2009

Last Update Submit

March 15, 2010

Conditions

Keywords

Inhalation profilesasthmaCOPD

Outcome Measures

Primary Outcomes (1)

  • Peak Inspiratory Flow Rate

    Day 3-10

Secondary Outcomes (4)

  • Pressure Slope

    Day 3-10

  • Peak Pressure Drop

    Day 3-10

  • Time to Peak Pressure Drop

    Day 3-10

  • Inhaled Volume

    Day 3-10

Study Arms (1)

Dry Powder Inhalers

Device: CRC-749Device: DiskusDevice: TwisthalerDevice: Miat Monohaler

Interventions

CRC-749DEVICE

There is no drug being used. This is a device.

Dry Powder Inhalers
DiskusDEVICE

There is no drug being used. This is a device.

Dry Powder Inhalers

There is no drug being used. This is a device.

Dry Powder Inhalers

There is no drug being used. This is a device.

Dry Powder Inhalers

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Asthma and COPD patients

You may qualify if:

  • Subjects with a physician documented history or diagnosis of asthma for at least 6 months
  • Reversibility, defined as an increase in FEV1 at the Screening visit of greater than or equal to 12% and 200 mL
  • Subjects with a physician documented history or diagnosis of mild or severe Chronic Obstructive Pulmonary Disease

You may not qualify if:

  • Female subjects who are pregnant
  • Subjects who have a history of life-threatening asthma/COPD or who have experienced two or more exacerbations requiring hospitalization in the 12 months prior to screening
  • Evidence of lower respiratory tract infection
  • Subjects diagnosed with pulmonary fibrosis, bronchiectasis, pneumoconiosis, sarcoidosis or tuberculosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pfizer Investigational Site

Berlin, 10117, Germany

Location

Related Links

MeSH Terms

Conditions

AsthmaPulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

September 24, 2009

First Posted

December 16, 2009

Study Start

November 1, 2009

Primary Completion

February 1, 2010

Study Completion

February 1, 2010

Last Updated

March 17, 2010

Record last verified: 2010-03

Locations