Preemptive Analgesia in Cruciate Reconstruction
Comparing Etoricoxib and Celecoxib for Preemptive Analgesia for Acute Postoperative Pain in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial
1 other identifier
interventional
30
1 country
1
Brief Summary
The aims of this study was to compare analgesic efficacy of preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction. One hundred and two patients diagnosed as anterior cruciate ligament injury will randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients will be operated by one orthopaedic surgeon under regional anesthesia. Each group will be given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for rescue pain control and adverse events will be recorded periodically to 48 hours after surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started Jan 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2009
CompletedFirst Submitted
Initial submission to the registry
November 17, 2009
CompletedFirst Posted
Study publicly available on registry
November 20, 2009
CompletedNovember 20, 2009
November 1, 2009
1 year
November 17, 2009
November 19, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
VAS score
6,12,24,48 hour postoperative
Secondary Outcomes (1)
number of analgesic used
48 hour postoperative
Study Arms (1)
placebo
EXPERIMENTALidentical placebo
Interventions
Eligibility Criteria
You may qualify if:
- patients with anterior cruciate ligament injury age 15-50 yr
You may not qualify if:
- previous knee surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Prince of Songkla University
Hat Yai, Changwat Songkhla, 90110, Thailand
Related Publications (1)
Boonriong T, Tangtrakulwanich B, Glabglay P, Nimmaanrat S. Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain in patients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial. BMC Musculoskelet Disord. 2010 Oct 25;11:246. doi: 10.1186/1471-2474-11-246.
PMID: 20973952DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Boonsin Tangtrakulwanich, MD.,Ph.D
Faculty of Medicine, Prince of Songkla University
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 17, 2009
First Posted
November 20, 2009
Study Start
January 1, 2008
Primary Completion
January 1, 2009
Study Completion
June 1, 2009
Last Updated
November 20, 2009
Record last verified: 2009-11