A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
A Reduced 11 Beta Hydroxysteroid Dehydrogenase 2 (11 Beta HSD2) Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
1 other identifier
interventional
100
1 country
1
Brief Summary
Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines. An assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2009
CompletedFirst Submitted
Initial submission to the registry
November 5, 2009
CompletedFirst Posted
Study publicly available on registry
November 6, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2010
CompletedMay 25, 2011
May 1, 2011
1.1 years
November 5, 2009
May 24, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
Salt sensitivity, arterial hypertension
day 0, 14, 52, 156, 208, yearly
Study Arms (1)
1
OTHERInterventions
High salt diet: 150mmol/d Low salt diet: 30mmol/d
Eligibility Criteria
You may qualify if:
- acceptance for living kidney donation
You may not qualify if:
- withdrawal of consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of nephrology and hypertension, Universitiy of Bern
Bern, Canton of Bern, 3010, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Felix J Frey, Prof
University of Berne
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 5, 2009
First Posted
November 6, 2009
Study Start
June 1, 2009
Primary Completion
July 1, 2010
Study Completion
July 1, 2010
Last Updated
May 25, 2011
Record last verified: 2011-05