NCT00998647

Brief Summary

The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jun 2009

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2009

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

October 19, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 20, 2009

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2010

Completed
Last Updated

April 23, 2010

Status Verified

October 1, 2009

Enrollment Period

10 months

First QC Date

October 19, 2009

Last Update Submit

April 22, 2010

Conditions

Keywords

modified ultrafiltrationcardiac surgeryROTEMMultiple Electrode Aggregometry

Outcome Measures

Primary Outcomes (1)

  • ex vivo platelet aggregation (TRAPtest)

    20 min after filtration

Secondary Outcomes (5)

  • secondary hemostasis assessed by ROTEM

    20 min before and after filtration

  • blood loss

    24 h after filtration

  • kind and number of transfused blood products

    24h after filtration

  • conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration)

    20 min before and after filtration

  • rate of rethoracotomy for bleeding

    24h after filtration

Study Arms (2)

with modified ultrafiltration

elective cardiac surgery patients undergoing complex surgical intervention: coronary artery bypass grafting AND valve surgery double valve surgery aortic surgery Re-Dos

Device: modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus

without modified ultrafiltration

elective cardiac surgery patients undergoing complex surgical intervention: coronary artery bypass grafting AND valve surgery double valve surgery aortic surgery Re-Dos

Device: modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus

Interventions

usage of modified ultrafiltration following extracorporeal circulation; filtration about 1,5 liters and re-fill with colloids

Also known as: Maquet haemoconcentrator, BC 20 plus
with modified ultrafiltrationwithout modified ultrafiltration

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

electice cardiac surgery patients undergoing complex procedures: CABG and valve double-valve aortic surgery Re-Dos

You may qualify if:

  • patients undergoing complex cardiac surgery procedures

You may not qualify if:

  • none

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Goethe University hospital, Clinic for Anaesthesioloy

Frankfurt am Main, 60590, Germany

Location

Related Publications (2)

  • Boodhwani M, Williams K, Babaev A, Gill G, Saleem N, Rubens FD. Ultrafiltration reduces blood transfusions following cardiac surgery: A meta-analysis. Eur J Cardiothorac Surg. 2006 Dec;30(6):892-7. doi: 10.1016/j.ejcts.2006.09.014. Epub 2006 Oct 13.

    PMID: 17046273BACKGROUND
  • Weber CF, Jambor C, Strasser C, Moritz A, Papadopoulos N, Zacharowski K, Meininger D. Normovolemic modified ultrafiltration is associated with better preserved platelet function and less postoperative blood loss in patients undergoing complex cardiac surgery: a randomized and controlled study. J Thorac Cardiovasc Surg. 2011 May;141(5):1298-304. doi: 10.1016/j.jtcvs.2010.09.057. Epub 2010 Dec 3.

MeSH Terms

Conditions

Hemostatic DisordersHemorrhage

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesHemorrhagic DisordersHematologic DiseasesHemic and Lymphatic DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Christian F Weber, Dr.

    Goethe University Frankfurt, Clinic for Anaesthesiology, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 19, 2009

First Posted

October 20, 2009

Study Start

June 1, 2009

Primary Completion

April 1, 2010

Study Completion

April 1, 2010

Last Updated

April 23, 2010

Record last verified: 2009-10

Locations