Neurocognitive Enhancement in Major Depressive Disorder

NCT00998569 | Completed

• 1 other identifier: PSYC-092-09
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the effects of neurocognitive enhancement on cognitive abilities and related social and adaptive behaviours in individuals diagnosed with major depressive disorder. Subjects in this study will be randomized to receive Neurocognitive Enhancement Therapy (NET) or to a wait list and then NET . Secondary aims include examining whether the cognitive benefits are potentiated by repeated exposure during in-home practice with complementary exercises. Additionally, the investigators will examine the durability of the effects and their generalization to functional capacity and everyday functional performance after completion of the groups.

Conditions

Major Depressive Disorder

Outcome Measures

Primary Outcomes (1)

• Performance on paper and pencil assessments of neurocognition after treatment, compared to baseline assessment performance

  20 weeks

Study Arms (2)

Neurocognitive Enhancement

EXPERIMENTAL

neurocongnitive enhancement

Behavioral: Neurocognitive Enhancement

Wait List

OTHER

no intervention

Behavioral: Wait List

Interventions

Neurocognitive Enhancement BEHAVIORAL

Neurocognitive Enhancement Therapy (NET) uses behavioural treatment strategies that are designed to improve a range of cognitive skills. NET uses strategies such as coaching, repetition, practice, teaching, group discussion, and compensation for deficits by using cognitive strengths.

Neurocognitive Enhancement

Wait List BEHAVIORAL

Participants will be wait listed for 10 weeks, following which time they will receive the intervention previously described.

Wait List

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or Female.
• Subjects will be between the ages of 18 and 65, which is the age range with available normative comparison data.

You may not qualify if:

• Presence of a medical diagnosis that is associated with known cognitive impairments, such as multiple sclerosis, cerebrovascular accident, dementia, or history of traumatic brain injury.
• Subjects with a reading level below grade 6, as assessed with the Wide Range Achievement Test - Reading Recognition Subtest, will be excluded because of the likelihood of not understanding task instructions.
• Subjects with uncorrectable vision or hearing impairment that would preclude valid assessments or intervention procedures.

Sponsors & Collaborators

• Queen's University: lead

Study Sites (1)

Queen's University

Kingston, Ontario, K7L 3N6, Canada

Location

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

Waiting Lists

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Appointments and Schedules; Organization and Administration; Health Services Administration

Study Officials

• Christopher Bowie, PhD

  Queen's University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ph.D.

Study Record Dates

• First Submitted: October 14, 2009
• First Posted: October 20, 2009
• Study Start: October 1, 2009
• Primary Completion: March 1, 2012
• Study Completion: March 1, 2012
• Last Updated: August 31, 2015

Record last verified: 2015-08

Locations

CA (1)