Breastfeeding in Infancy and Food Intake in Preschool-Aged Children

NCT00994487 | Completed DMC

• 1 other identifier: 7828B
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to compare female, preschool-aged children breastfed during infancy to female, preschool-aged children bottle-fed during infancy in their ability to adjust calorie intake in response to internal signals of hunger and fullness. Children and a parent will come to two sessions, with the children given drinks that are either high or low in energy, and then consume a lunch following the drink. The parent will be present during the lunch. Greater ability to self-regulate intake is demonstrated when less energy is consumed at lunch following the high energy drink as compared to the lunch following the low energy drink. Lunches will be videotaped so that parental feeding styles (i.e., how the parent interacted with the child during lunch) can be examined. The primary hypotheses are: 1.) the exclusively breastfed children will have higher self-regulation ability than the exclusively bottle-fed children, and 2.) the mothers of the exclusively breastfed children will demonstrate a parental feeding style characterized by less control and restriction than the mothers (or parent primarily responsible for child feeding) of the exclusively bottle-fed children.

Conditions

Childhood Obesity; Breastfeeding

Keywords

Childhood Obesity; Breastfeeding; Bottle Feeding; Dietary Intake; Preload; Compensation; Parental Feeding Style

Outcome Measures

Primary Outcomes (1)

• Compensation for high energy density and low energy density preloads

  2 days

Secondary Outcomes (1)

• Parental feeding style

  2 days

Study Arms (2)

Breastfed child

EXPERIMENTAL

Female, normal weight, 3 to 5 year old children, exclusively breastfed from birth to 3 months of age

Other: High Energy Density Preload; Other: Low Energy Density Preload

Bottle Fed Child

ACTIVE COMPARATOR

Female, normal weight, 3 to 5 year old children, exclusively bottle fed from birth to 3 months of age

Other: High Energy Density Preload; Other: Low Energy Density Preload

Interventions

High Energy Density Preload OTHER

Each child with a parent will attend a lunch session. In these sessions children will drink a liquid preload that is high in energy density and then they will consume an ad libitum lunch. The ad libitum lunch will be videotaped, and the videotapes will be coded for parental feeding styles

Bottle Fed Child; Breastfed child

Low Energy Density Preload OTHER

Each child with a parent will attend a lunch session. In these sessions children will drink a liquid preload that is low in energy density and then they will consume an ad libitum lunch. The ad libitum lunch will be videotaped, and the videotapes will be coded for parental feeding styles.

Bottle Fed Child; Breastfed child

Eligibility Criteria

• Age: 3 Years - 5 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children will be eligible for study participation if they meet the following criteria:
• female
• BMI between the 5th and the 85th percentile
• were of normal birth weight (\>2500 g)
• full-term
• have no chronic disease conditions effecting growth and intake
• have not been in foster care for longer than one month (if at all)
• are between 3 and 5 years of age
• are willing to consume and are not allergic to the preloads and meals used in the study
• are not lactose-intolerant
• have a parent who is able to recall mode of feeding in infancy and was either exclusively breast-fed from birth to 3 months of age (defined as being fed from a bottle on average \< 1 time per week from birth to 3 months of age, with all other feedings from the breast) or was exclusively bottle-fed from birth to 3 months of age (defined as being completely bottle-fed, with feedings comprised of formula and/or breastmilk)
• have a parent willing to transport child to the University of Tennessee lab at two different times during their participation in the project

Sponsors & Collaborators

• The University of Tennessee, Knoxville: lead

Study Sites (1)

University of Tennessee

Knoxville, Tennessee, 37996, United States

Location

Related Links

• Website for the Healthy Eating and Activity Laboratory (HEAL) where the study is conducted

MeSH Terms

Conditions

Pediatric Obesity; Breast Feeding; Bottle Feeding

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Feeding Behavior; Behavior

Study Officials

• Hollie A Raynor, PhD

  University of Tennessee

  PRINCIPAL INVESTIGATOR

• Katie Kavanagh, PhD

  Univerisity of Tennessee

  STUDY CHAIR

• Hiliary Fouts, PhD

  University of Tennessee

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 12, 2009
• First Posted: October 14, 2009
• Study Start: June 1, 2010
• Primary Completion: June 1, 2010
• Study Completion: July 1, 2010
• Last Updated: April 5, 2018

Record last verified: 2018-04

Locations

US (1)