A Model to Identify Specific Predictors of Spatial Neglect Recovery

NCT00990353 | Unknown DMC

• 2 other identifiers: D-624-081R01NS055808
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 3

Brief Summary

This study examines methods to better predict improvement of a hidden disability of functional vision, spatial neglect, following stroke. Spatial neglect is a tendency to make visual judgment and movement errors mislocating the body and objects in space. The investigators are using specialized statistical methods to compute the proportion of improvement accounted for by personal characteristics of each stroke survivor, the proportion of improvement accounted for by the unique visual-spatial errors made by each subject, and the proportion of improvement accounted for by each treatment administered. The investigators will also examine whether brain imaging predicts how rapidly improvement occurs. Lastly, the study tests whether improvements that are meaningful to the survivor can be measured in a way that still allows detection of small and scientifically eloquent performance changes.

Conditions

Spatial Neglect; Hemispatial Neglect; Hemineglect; Unilateral Neglect; Visual Spatial Neglect; Sensory Neglect

Keywords

Spatial neglect; hemineglect; stroke; cognition; prism adaptation; Hierarchical linear modeling; growth curve modeling

Outcome Measures

Primary Outcomes (1)

• Comparing two treatments for hidden disabilities in functional vision after stroke.

  6 months

Study Arms (2)

Prism adaptation therapy

Patients receive prism adaptation therapy by protocol (Frassinetti et al., 2002)

Bromocriptine pharmacotherapy

Patients receive bromocriptine pharmacotherapy by protocol (Barrett et al., 1999)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stroke survivors with right brain stroke and evidence of a hidden disability of functional vision (spatial neglect)

You may qualify if:

• Stroke survivors with right brain stroke and evidence of a hidden disability of functional vision (spatial neglect)
• Can give consent

You may not qualify if:

• Other neurological conditions

Sponsors & Collaborators

• Kessler Foundation: lead
• National Institute of Neurological Disorders and Stroke (NINDS): collaborator
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator

Study Sites (3)

Kessler Institute of Rehabilitation

Chester, New Jersey, 07930, United States

Location

Kessler Institute of Rehabilitation

Saddle Brook, New Jersey, 07663, United States

Location

Kessler Foundation Research Center

West Orange, New Jersey, 07052, United States

Location

Related Publications (1)

• Boukrina O, Chen P, Budinoska T, Barrett AM. Exploratory examination of lexical and neuroanatomic correlates of neglect dyslexia. Neuropsychology. 2020 May;34(4):404-419. doi: 10.1037/neu0000619. Epub 2020 Jan 30.

  PMID: 31999167 DERIVED

Related Links

• Kessler Foundation

MeSH Terms

Conditions

Perceptual Disorders; Stroke

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• A M Barrett, MD

  Kessler Foundation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Stroke Research

Study Record Dates

• First Submitted: July 27, 2009
• First Posted: October 6, 2009
• Study Start: January 1, 2009
• Primary Completion: October 1, 2021
• Study Completion: October 1, 2021
• Last Updated: February 17, 2021

Record last verified: 2021-02

Locations

US (3)