NCT00982059|CompletedDMC
Colorectal Cancer Screening for Cancer Survivors
Colorectal Cancer Screening in Cancer Survivors Treated With Radiation Therapy
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Colorectal Cancer Screening in Cancer Survivors Treated With Radiation Therapy
Sponsor study identifier
observational
140
2 countries
2
Study Start
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2014
Actual (reported)Study Completion
January 24, 2018
Actual (reported)The risk of colorectal cancer (CRC) is significant among cancer survivors treated with abdominal radiation therapy (RT). Further, CRC is once of the few cancers for which there is effective screening. Although some expert groups recommend early CRC screening for patients with prior abdominal RT, the effectiveness of early screening is unknown. It is also unknown if radiation-induced CRC passes through a "pre-clinical" phase in which precancerous polyps are detectable and treatable prior to becoming invasive cancers. This study will evaluate whether screening will detect pre-invasive colorectal polyps among survivors treated with RT.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 24, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
November 21, 2008
Actual (reported)September 22, 2009
Actual (reported)December 2014
Actual (reported)January 24, 2018
Actual (reported)The proportion of screened patients with any polyp or any high risk polyp will be calculated.
3 years
Proportion calculation/identification of: demographic/treatment influences on polyp prevalence; subgroups w/polyp prevalence >20%; pts with polyps beyond 30cm flexible sigmoidoscope; pts with adenomatous polyp(s) on colonoscopy in/outside prior RT fields
3 years
All patients enrolled in the study will be undergoing the same procedures.
All patients enrolled in the study will undergo a colonoscopic examination and complete a baseline questionnaire.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients who have received radiation treatment to the abdomen,pelvis or spine.
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
University Health Network
Toronto, Ontario, M5G 2M9, Canada
Daly PE, Samiee S, Cino M, Gryfe R, Pollett A, Ng A, Constine LS, Hodgson DC. High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial. Gut. 2017 Oct;66(10):1797-1801. doi: 10.1136/gutjnl-2016-311501. Epub 2016 Jul 13.
David Hodgson, MD
University Health Network, Princess Margaret Hospital
Andrea K Ng, MD
Dana-Farber Cancer Institute
First Submitted
November 21, 2008
First Posted
September 22, 2009
Study Start
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2014
Actual (reported)Evaluation of an Intervention to Increase Colorectal Cancer Screening in Primary Care Clinics
Contact the study team to confirm eligibility.
Study Completion
January 24, 2018
Actual (reported)Last Updated
January 31, 2018
Record last verified: 2018-01
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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