Functional Magnetic Resonance Imaging (fMRI) Imaging Study in Adolescents With Anorexia Nervosa

NCT00978666 | Completed DMC

• 2 other identifiers: 090008R21MH086017
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to use fMRI imaging technology to examine areas in the brain related to appetite, reward and cognition in adolescent women with eating disorders as compared to those who have never had an eating disorder. Better understanding biologic vulnerabilities in women with anorexia is essential for developing more effective treatment options.

Conditions

Anorexia Nervosa

Study Arms (2)

Healthy controls

Healthy comparison adolescent females

Anorexia Nervosa

Adolescent females currently ill with Anorexia Nervosa, restricting type

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants with anorexia nervosa will be selected from the community as well as from local medical clinics and eating disorder treatment centers. Healthy volunteers will be selected from the community at large.

You may qualify if:

• Female
• Ages 12-18
• Right Handed
• Active AN diagnosis (within last 6 months), excluding amenorrhea criteria

You may not qualify if:

• Male
• Left Handed
• Does not meet AN criteria within last 6 months
• Alcohol/drug dependence in the 3 months prior to study
• Alcohol/drug use within the 30 days prior to scan. Tox Screen will be administered at GCRC.
• Use of antipsychotic medication in 3 months prior to study (SSRI OK)
• Current diagnosis of severe major effective d/o or anxiety d/o or other psychopathology that might interfere with ability to participate e.g requiring inpatient hospitalization or medication
• Pregnancy or lactation
• Organic brain syndromes, dementia, psychotic disorders or mental retardation
• Neurological or medical disorders such as seizure disorder, renal disease including pyelonephritis and chronic cystitis, impaired renal function including hyponatremia (less than 135meq/l), hypokalemia, raised BUN (more than 15mg/dl), diabetes, thyroid disease (hypo and hyper), EKG indicative of electrolyte imbalance
• Lack of effective birth control during 15 days before the scan. A Urine pregnancy test will be conducted within 24 hours of the scan
• Insufficient English
• Female
• Ages 12-18
• Right Handed

Sponsors & Collaborators

• University of California, San Diego: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

UCSD Eating Disorder Treatment and Research Program

La Jolla, California, 92037, United States

Location

Related Links

• Related Info

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 16, 2009
• First Posted: September 17, 2009
• Study Start: June 1, 2009
• Primary Completion: August 1, 2011
• Study Completion: November 1, 2019
• Last Updated: November 14, 2019

Record last verified: 2019-11

Locations

US (1)