The Relationship Between the Response to Mental Stress and Vascular Endothelial Function

NCT00975559 | Completed

• 1 other identifier: 1881-03
• Study Type: observational
• Target: 190
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects. In one part of the study the investigators will compare the cardiovascular responses to mental stress between healthy women and healthy men. In another part of the study, the investigators will compare the cardiovascular responses to mental stress between women with apical ballooning syndrome and healthy post-menopausal women. The investigators hypothesize that healthy men will have an increased vascular response to and decreased endothelial function in response to to mental stress, compared to health women. Furthermore, the investigators hypothesize that women with apical ballooning syndrome will have an increased vascular response to and decreased endothelial function in response to mental stress.

Conditions

Coronary Endothelial Dysfunction; Apical Ballooning Syndrome; Myocardial Infarction

Study Arms (4)

Normal volunteers

Normal study volunteers with no prior history of coronary artery disease

Apical Ballooning Syndrome

Women who have had a documented Apical Ballooning event as shown by coronary angiogram

Coronary Endothelial Dysfunction

Patients who have been diagnosed with Endothelial Dysfunction via a coronary angiogram with acetylcholine challenge

Myocardial Infarction

Women diagnosed with a Myocardial Infarction who subsequently had a Percutaneous Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Normal volunteers 2. Apical Ballooning syndrome as proven during coronary angiogram 3. Coronary Endothelial Dysfunction as proven during coronary angiogram 4. Women who have had a Myocardial Infarction with subsequent Percutaneous Intervention

You may qualify if:

• Patients must be identified in one of the four groups outlined in "study population description."

You may not qualify if:

• Other co-morbidities that would make the testing not possible.
• Women who have had a mastectomy and would not have an arm that could be occluded during the reactive hyperemia portion of the Peripheral arterial tonometry testing.

Sponsors & Collaborators

• Mayo Clinic: lead
• United States Department of Defense: collaborator

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Catecholomines

MeSH Terms

Conditions

Takotsubo Cardiomyopathy; Myocardial Infarction

Condition Hierarchy (Ancestors)

Cardiomyopathies; Heart Diseases; Cardiovascular Diseases; Ventricular Dysfunction, Left; Ventricular Dysfunction; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: September 9, 2009
• First Posted: September 11, 2009
• Study Start: September 1, 2003
• Primary Completion: April 1, 2011
• Study Completion: April 1, 2011
• Last Updated: April 26, 2012

Record last verified: 2012-04

Locations

US (1)