NCT00975390

Brief Summary

The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes. The investigators hypothesize that both interventions (the addition of caffeine or protein+leucine) will lead to higher glycogen re-synthesis compared to the ingestion of CHO only, and that the co-ingestion of protein and leucine will result in the highest muscle glycogen synthesis rates.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2009

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2009

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2009

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

September 10, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 11, 2009

Completed
Last Updated

April 14, 2015

Status Verified

April 1, 2015

Enrollment Period

7 months

First QC Date

September 10, 2009

Last Update Submit

April 13, 2015

Conditions

Exercise Recovery

Keywords

GlycogenCarbohydrateProteinCaffeinePost exercise muscle glycogen synthesisSports nutrition

Outcome Measures

Primary Outcomes (1)

  • Muscle glycogen synthesis rates

    6 hours

Secondary Outcomes (1)

  • Glycogen synthase activity, plasma glucose, insulin, free fatty acids and epinephrine responses

    6 hours

Study Arms (3)

1

EXPERIMENTAL

Carbohydrate ingestion

Dietary Supplement: Carbohydrate

2

EXPERIMENTAL

Carbohydrate and protein ingestion

Dietary Supplement: Carbohydrate and protein ingestion

3

EXPERIMENTAL

Carbohydrate and caffeine ingestion

Dietary Supplement: Carbohydrate and caffeine ingestion

Interventions

CarbohydrateDIETARY_SUPPLEMENT

1.2 g/kg/h

1
Carbohydrate and protein ingestionDIETARY_SUPPLEMENT

1.2 g/kg/h carbohydrate plus 0.4 g/kg/h protein

2
Carbohydrate and caffeine ingestionDIETARY_SUPPLEMENT

1.2 g/kg/h carbohydrate and 1.67 g/kg/h caffeine

3

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • male cyclists
  • healthy
  • BMI \< 25

You may not qualify if:

  • female
  • use of medication
  • non cycling
  • BMI \> 25

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Maastricht University

Maastricht, Netherlands

Location

MeSH Terms

Interventions

Carbohydrates

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr.

Study Record Dates

First Submitted

September 10, 2009

First Posted

September 11, 2009

Study Start

February 1, 2009

Primary Completion

September 1, 2009

Study Completion

September 1, 2009

Last Updated

April 14, 2015

Record last verified: 2015-04

Locations

NL(1)