NCT00974610

Brief Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in peptides and proteins and identify biomarkers related to cancer. PURPOSE: This research study is looking at blood samples from patients with malignant melanoma, metastatic breast cancer, advanced lung cancer, pancreatic cancer, or colorectal cancer.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
803

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2008

Longer than P75 for all trials

Geographic Reach
1 country

13 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2008

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

September 9, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 10, 2009

Completed
6.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2017

Completed
Last Updated

May 24, 2017

Status Verified

May 1, 2017

Enrollment Period

7.3 years

First QC Date

September 9, 2009

Last Update Submit

May 23, 2017

Conditions

Keywords

stage IV melanomarecurrent melanomastage IV non-small cell lung cancerrecurrent non-small cell lung cancerextensive stage small cell lung cancerrecurrent small cell lung cancerstage IV breast cancerrecurrent breast cancermale breast cancerstage III pancreatic cancerstage IV pancreatic cancerrecurrent pancreatic cancerstage IV colon cancerrecurrent colon cancerstage IV rectal cancerrecurrent rectal cancer

Outcome Measures

Primary Outcomes (1)

  • Detection of peptide and protein markers in serum

    Ongoing

Secondary Outcomes (1)

  • Identification of the protein/peptide involved

    Ongoing

Study Arms (5)

Breast

Lung

Melanoma

Pancreatic

Colorectal

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

5 different tumour types

DISEASE CHARACTERISTICS: * Diagnosis of 1 of the following advanced metastatic malignancies: * Malignant melanoma * Lung cancer * Breast cancer * Pancreatic carcinoma * Colorectal cancer * Advanced and/or metastatic disease * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (13)

Cork University Hospital

Cork, Ireland

Location

Mercy University Hospital

Cork, Ireland

Location

Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital

Dublin, 24, Ireland

Location

St. Vincent's University Hospital

Dublin, 4, Ireland

Location

Mater Misericordiae University Hospital

Dublin, 7, Ireland

Location

St. James's Hospital

Dublin, 8, Ireland

Location

Beaumont Hospital

Dublin, 9, Ireland

Location

Mater Private Hospital

Dublin, Ireland

Location

St Luke's Hospital

Dublin, Ireland

Location

University College Hospital

Galway, Ireland

Location

Letterkenny General Hospital

Letterkenny, Ireland

Location

Mid-Western Cancer Centre at Mid-Western Regional Hospital

Limerick, 0009, Ireland

Location

Waterford Regional Hospital

Waterford, Ireland

Location

MeSH Terms

Conditions

Breast NeoplasmsColorectal NeoplasmsLung NeoplasmsMelanomaPancreatic NeoplasmsCarcinoma, Non-Small-Cell LungSmall Cell Lung CarcinomaBreast Neoplasms, MaleColonic NeoplasmsRectal Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue DiseasesIntestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal DiseasesRespiratory Tract NeoplasmsThoracic NeoplasmsLung DiseasesRespiratory Tract DiseasesNeuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic TypeNeoplasms, Nerve TissueNevi and MelanomasSkin NeoplasmsEndocrine Gland NeoplasmsPancreatic DiseasesEndocrine System DiseasesCarcinoma, BronchogenicBronchial Neoplasms

Study Officials

  • Martin Clynes

    National Institute for Cellular Biotechnology at Dublin City University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 9, 2009

First Posted

September 10, 2009

Study Start

August 1, 2008

Primary Completion

December 1, 2015

Study Completion

January 1, 2017

Last Updated

May 24, 2017

Record last verified: 2017-05

Locations