"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up

NCT00960817 | Unknown Early Phase 1

• 1 other identifier: HYMC 02/2009
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery. The investigators believe that they have small vessel coronary disease which is the initial presentation of coronary disease prior to anatomical narrowing. To alleviate this phenomenon the investigators intend to examine the long-term clinical response of these patients to treatment with dipyridamole, a well-known medication with almost no side-effects that increases the level of adenosine in the tissue.

Conditions

Coronary Angiography

Keywords

Normal coronary artery with slow blood flow

Outcome Measures

Primary Outcomes (1)

• Alleviation of chest pain

  Two years

Study Arms (2)

1. Routine treatment

ACTIVE COMPARATOR

Control group

Drug: Statin, aspirin

2. Dipyridamole treatment

EXPERIMENTAL

Group that receives Dipyridamole treatment

Drug: Dipyridamole

Interventions

Statin, aspirin DRUG

1. Routine treatment

Dipyridamole DRUG

2. Dipyridamole treatment

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients undergoing coronary angiography and who have normal coronary artery with slow blood flow that normalized with adenosine injection into the coronary artery

You may not qualify if:

• Significant coronary disease
• Unstable patients
• Patients with known sensitivity to dipyridamole

Sponsors & Collaborators

• Hillel Yaffe Medical Center: lead

Study Sites (1)

Hillel Yaffe Medical Center

Hadera, 38100, Israel

Location

MeSH Terms

Interventions

Hydroxymethylglutaryl-CoA Reductase Inhibitors; Aspirin; Dipyridamole

Intervention Hierarchy (Ancestors)

Anticholesteremic Agents; Hypolipidemic Agents; Antimetabolites; Molecular Mechanisms of Pharmacological Action; Pharmacologic Actions; Chemical Actions and Uses; Enzyme Inhibitors; Lipid Regulating Agents; Therapeutic Uses; Salicylates; Hydroxybenzoates; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: early phase 1
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: August 17, 2009
• First Posted: August 18, 2009
• Last Updated: August 18, 2009

Record last verified: 2009-08

Locations

IL (1)