The Effect of Perthes' Disease on Hip Cartilage

NCT00958464 | Completed

• 1 other identifier: H07-00930
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether Perthes' disease has caused detectable hip cartilage damage in young people who have reached the healed stage of the disease.

Conditions

Perthes' Disease

Keywords

MRI; Perthes'disease; hip; cartilage

Outcome Measures

Primary Outcomes (1)

• Whether Perthes' disease has caused detectable hip cartilage damage in young people who have reached the healed stage of the disease.

  2 days

Study Arms (1)

1

MRI protocol on 2 separate occasions

Procedure: MRI

Interventions

MRI PROCEDURE

MRI protocol consists of intravenous injection of 0.4 ml/kg dose of gadopentetate dimeglumine 2- \[Gd-DTPA2-\] contrast agent (Magnevist, Bayer) 90 minutes prior to imaging.

1

Eligibility Criteria

• Age: 17 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Volunteers with healed unilateral Perthes' disease between the ages of 7-18 years

You may qualify if:

• Subjects must have reached the healed stage of unilateral Perthes' disease. -Subjects will be between 7 and 18 years of age.
• Subjects must understand English.

You may not qualify if:

• Subjects will be excluded if they have bilateral Perthes' disease or if they have not yet reached the healing stage of the disease.
• Subjects will also be excluded if they do not meet the criteria to have an MRI (e.g., the subject has metal implants, is claustrophobic, has a metallic object in eye or a pacemaker).
• A subject will be excluded if they have any of the precautions for the MR contrast agent, Magnevist, such as pregnancy, breast-feeding, respiratory allergies, asthma, thrombotic syndromes, history of grand mal seizures, impaired renal or hepatic function.

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

BC Children's Hospital, Department of Orthopaedics

Vancouver, British Columbia, Canada

Location

MeSH Terms

Conditions

Legg-Calve-Perthes Disease

Condition Hierarchy (Ancestors)

Femur Head Necrosis; Osteonecrosis; Bone Diseases; Musculoskeletal Diseases

Study Officials

• Kishore Mulpuri, Dr.

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• David Wilson, Dr.

  University of British Columbia

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: August 11, 2009
• First Posted: August 13, 2009
• Study Start: January 1, 2008
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: October 3, 2019

Record last verified: 2019-10

Locations

CA (1)