NCT00957710

Brief Summary

Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. The aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. The first goal of this study is to improve naming abilities of individuals with progressive aphasia. This will be accomplished by carrying out an intensive treatment program for anomia. The second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional Magnetic Resonance Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging tractography (to measure the connectivity between specific brain regions). This is the first study on progressive aphasia addressing both treatment and imaging in the same patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
7

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Aug 2009

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2009

Completed
10 days until next milestone

First Submitted

Initial submission to the registry

August 11, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 12, 2009

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2010

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2010

Completed
Last Updated

January 27, 2015

Status Verified

January 1, 2015

Enrollment Period

11 months

First QC Date

August 11, 2009

Last Update Submit

January 26, 2015

Conditions

Primary Progressive AphasiaNonfluent Progressive AphasiaSemantic Dementia

Keywords

progressive aphasiasemantic dementianeuroimagingtreatmenterrorless learning

Outcome Measures

Primary Outcomes (1)

  • Accuracy of picture naming

    3 months

Secondary Outcomes (1)

  • Changes on neuroimaging

    3 months

Study Arms (1)

langauge therapy

OTHER

Naming therapy

Behavioral: Errorless learning

Interventions

Errorless learningBEHAVIORAL

Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls

Also known as: treatment for anomia
langauge therapy

Eligibility Criteria

Age40 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of progressive aphasia
  • Native English speaker or fluent in English
  • Adequate hearing and vision (not requiring more than +6 diopter correction)
  • Willing and able to participate in each phase of the study (including two fMRI sessions)

You may not qualify if:

  • Contraindications to fMRI (e.g., claustrophobia, pacemaker, ferromagnetic implant)
  • Current medical or psychiatric condition affecting cognition (other than progressive aphasia)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Baycrest

Toronto, Ontario, M6A 2E1, Canada

Location

Related Publications (4)

  • Jokel R, Rochon E, Anderson ND. Errorless learning of computer-generated words in a patient with semantic dementia. Neuropsychol Rehabil. 2010 Jan;20(1):16-41. doi: 10.1080/09602010902879859.

    PMID: 19504403BACKGROUND

  • Jokel R, Rochon E, Leonard C. Treating anomia in semantic dementia: improvement, maintenance, or both? Neuropsychol Rehabil. 2006 Jun;16(3):241-56. doi: 10.1080/09602010500176757.

    PMID: 16835150BACKGROUND

  • Jokel R, Rochon E, Leonard C. Therapy for anomia in semantic dementia. Brain Cogn. 2002 Jul;49(2):241-4.

    PMID: 15259401BACKGROUND

  • Jokel R, Cupit J, Rochon E, Leonard C. Relearning lost vocabulary in nonfluent progressive aphasia with Mosstalk Words. Aphasiology 23(2): 175-191, 2009

    BACKGROUND

MeSH Terms

Conditions

Aphasia, Primary ProgressivePrimary Progressive Nonfluent AphasiaFrontotemporal DementiaAphasia

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesSpeech DisordersLanguage DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental DisordersFrontotemporal Lobar DegenerationTDP-43 ProteinopathiesNeurodegenerative DiseasesProteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Regina Jokel, PhD

    Baycrest

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
clinician scientist

Study Record Dates

First Submitted

August 11, 2009

First Posted

August 12, 2009

Study Start

August 1, 2009

Primary Completion

July 1, 2010

Study Completion

December 1, 2010

Last Updated

January 27, 2015

Record last verified: 2015-01

Locations

CA(1)