Microbial Community Composition and Metabolism in Cystic Fibrosis

NCT00954018 | Completed

• 1 other identifier: 09-04-018
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Scientist have begun to realize that many types of bacteria often live together as a complex community, and the investigators wish to apply that idea to the bacteria in the respiratory system of people with Cystic Fibrosis (CF). It is possible that the survival of the many millions of bacteria in the CF lung depends on the production of special chemicals that might be made only by very few types of bacteria. If that is true, medicines that interfere with those chemicals could treat the lung infections that cause trouble for nearly all people with CF. The investigators wish to study the production of several potentially critical chemicals by the respiratory bacteria and to examine the effect of those chemicals on the makeup of the entire community of bacteria. To detect all the bacteria in that community, the investigators will use new methods that use bacterial genetic information and can detect hundreds of different types of bacteria in respiratory samples of individual CF patients.

Conditions

Cystic Fibrosis

Study Arms (3)

Cystic Fibrosis patient during outpatient clinic visit

Cystic Fibrosis patients during hospitalization

CF patients about to have sinus surgery and bronchoscopy

Eligibility Criteria

• Age: 2 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Cystic fibrosis patients will be contacted during clinical care visits and inpatient hospitalizations.

You may qualify if:

• confirmed diagnosis of Cystic Fibrosis
• to 55 years of age

You may not qualify if:

• None

Sponsors & Collaborators

• Boston Children's Hospital: lead
• Massachusetts Institute of Technology: collaborator
• Harvard Medical School (HMS and HSDM): collaborator

Study Sites (1)

Children's Hosptital, Boston

Boston, Massachusetts, 02115, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

throat swabs or sputum

MeSH Terms

Conditions

Cystic Fibrosis

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases; Lung Diseases; Respiratory Tract Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Pediatrics

Study Record Dates

• First Submitted: August 5, 2009
• First Posted: August 6, 2009
• Study Start: August 1, 2009
• Primary Completion: November 10, 2017
• Study Completion: November 10, 2017
• Last Updated: February 15, 2023

Record last verified: 2023-02

Locations

US (1)