NCT00952224

Brief Summary

In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury. This allows for quantifying the extent of salvaged myocardium after reperfusion as a potential strong end point for clinical trials and outcome. The aim of the present study is to determine the prognostic significance and determinants of myocardial salvage assessed by CMR in reperfused ST-elevation myocardial infarction (STEMI).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
267

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2006

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2006

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2008

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2009

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

August 3, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

August 6, 2009

Completed
Last Updated

August 6, 2009

Status Verified

August 1, 2009

Enrollment Period

1.5 years

First QC Date

August 3, 2009

Last Update Submit

August 4, 2009

Conditions

ST-Elevation Myocardial Infarction

Keywords

myocardial salvagecardiovascular magnetic resonancemagnetic resonance imagingmyocardial infarctionprognosis

Outcome Measures

Primary Outcomes (1)

  • Major adverse cardiac events

    6 months

Secondary Outcomes (1)

  • Mortality

    6 months

Study Arms (1)

Acute myocardial infarction patients

Patients undergoing primary percutaneous coronary intervention in ST-elevation myocardial infarction plus magnetic resonance imaging

Other: magnetic resonance imaging

Interventions

magnetic resonance imagingOTHER

magnetic resonance imaging is used for prognosis assessment

Acute myocardial infarction patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Cohort of patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

You may qualify if:

  • ST-elevation myocardial infarction \< 12 hours
  • primary percutaneous coronary intervention

You may not qualify if:

  • previous myocardial infarction
  • prior fibrinolysis
  • contraindications to CMR at study entry (such as implanted pacemakers, defibrillators, claustrophobia or metallic intracranial implants)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Leipzig - Heart Center

Leipzig, 04289, Germany

Location

Related Publications (2)

  • Eitel I, Desch S, de Waha S, Fuernau G, Gutberlet M, Schuler G, Thiele H. Long-term prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. Heart. 2011 Dec;97(24):2038-45. doi: 10.1136/heartjnl-2011-300098. Epub 2011 Oct 11.

    PMID: 21990384DERIVED

  • Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, Thiele H. Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol. 2010 Jun 1;55(22):2470-9. doi: 10.1016/j.jacc.2010.01.049.

    PMID: 20510214DERIVED

MeSH Terms

Conditions

ST Elevation Myocardial InfarctionMyocardial Infarction

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Intervention Hierarchy (Ancestors)

Spectrum AnalysisChemistry Techniques, AnalyticalInvestigative Techniques

Study Officials

  • Ingo Eitel, MD

    Heart Center Leipzig - University Hospital

    PRINCIPAL INVESTIGATOR

  • Holger Thiele, MD

    Heart Center Leipzig - University Hospital

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 3, 2009

First Posted

August 6, 2009

Study Start

November 1, 2006

Primary Completion

May 1, 2008

Study Completion

March 1, 2009

Last Updated

August 6, 2009

Record last verified: 2009-08

Locations

DE(1)