Application of Magnetic Resonance Fat-Free Imaging

NCT00944476 | Terminated

• 1 other identifier: 09-078
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

Magnetic resonance imaging (MRI) is presently the best study for assessing the size and extent of the patient's sarcoma. Many sarcomas contain fat that can interfere with the accuracy of sarcoma detection. The investigators have developed a new MRI method that can suppress all the fat signals in the patient's tumor and this may improve the investigators' ability to see the patient's sarcoma. The purpose of this study is to determine if the investigators' new fat-free imaging methods provides them with images that are better than, equal to, or worse than those images obtained by standard MRI methods. This study may help the investigators develop a more accurate MRI examination.

Conditions

Sarcoma

Keywords

Sarcoma; soft tissue; MRI; Questionnaire; 09-078

Outcome Measures

Primary Outcomes (1)

• To determine if our magnetization transfer fat-free imaging methods produce fat suppression images of sarcoma that are better, equal to or less in quality than fat-suppressed T2-weighted MRI images.

  2 years

Study Arms (1)

Pts/volunteers getting regular MRI exam

Fat-free MRI images utilizing standard magnetization transfer imaging will be acquired on 10 patients known or suspected sarcoma of the of the extremity or trunk, in addition to their traditional clinical MRI. In addition, we will perform the same scans on 4 volunteers who have no history of sarcoma.

Procedure: Fat-free MRI images utilizing standard magnetization, Questionnaire before the MRI exam

Interventions

Fat-free MRI images utilizing standard magnetization, Questionnaire before the MRI exam PROCEDURE

In addition to the traditional MRI exam for clinical use, a fat-free MRI based on standard magnetization transfer magnetic resonance imaging will be acquired. Pts will spend 20 extra minutes and 20 minutes total for volunteers in the MRI scanner. Patients/volunteers will complete the MR Screening Questionnaire before the MRI exam.

Pts/volunteers getting regular MRI exam

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential research participants from those patients who are/will be scheduled for MRI examination as part of their routine clinical care at MSKCC. Dr. Singer will also identify four volunteers with no history of sarcoma to participate in this study.

You may qualify if:

• Participant is capable of providing verbal consent.
• years of age or older.
• Participants will belong to one of the following two categories:
• Patient with a known or suspected soft tissue sarcoma of the extremity or trunk who is/will be scheduled for an MRI scan as part of their routine care, -OR--
• Volunteer with no history of sarcoma.

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead

Study Sites (1)

Memorial Sloan-Kettering CancerCenter

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan-Kettering Cancer Center

MeSH Terms

Conditions

Sarcoma

Condition Hierarchy (Ancestors)

Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms

Study Officials

• Samuel Singer, MD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2009
• First Posted: July 23, 2009
• Study Start: July 1, 2009
• Primary Completion: May 1, 2014
• Last Updated: May 15, 2014

Record last verified: 2014-05

Locations

US (1)