NCT00929539

Brief Summary

The purpose of this study is to evaluate the effect of JTT-130 on diabetes as well as the safety and tolerability of JTT-130 in obese Type 2 diabetic patients.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
496

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jun 2009

Shorter than P25 for phase_2

Geographic Reach
5 countries

62 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2009

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

June 26, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 29, 2009

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2010

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2010

Completed
Last Updated

February 4, 2013

Status Verified

January 1, 2013

Enrollment Period

11 months

First QC Date

June 26, 2009

Last Update Submit

January 31, 2013

Conditions

Keywords

Diabetes

Outcome Measures

Primary Outcomes (1)

  • Change in glycosylated hemoglobin (HbA1c) levels

    End of Study

Secondary Outcomes (1)

  • Safety and tolerability data

    End of Study

Study Arms (4)

Dose 1 JTT-130

EXPERIMENTAL
Drug: JTT-130

Dose 2 JTT-130

EXPERIMENTAL
Drug: JTT-130

Dose 3 JTT-130

EXPERIMENTAL
Drug: JTT-130

Placebo

PLACEBO COMPARATOR
Drug: JTT-130 Placebo

Interventions

Tablets

Dose 1 JTT-130Dose 2 JTT-130Dose 3 JTT-130

Tablets

Placebo

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Have type 2 diabetes;
  • Body mass index (BMI) of \> 27.0 kg/m2 and ≤ 45.0 kg/m2;
  • Are either drug naïve with respect to hypoglycemic agents OR are currently being treated with metformin alone or in combination with a sulfonylurea. Metformin and sulfonylurea dosing must be stable.

You may not qualify if:

  • Females who are pregnant or breast-feeding
  • Known medical history or presence of type 1 diabetes, pancreatitis, unstable or rapidly progressing retinopathy, nephropathy or neuropathy;
  • Acute coronary syndrome or uncontrolled hypertension;
  • Does not meet medication restriction criteria, as described in the protocol.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (62)

Unknown Facility

Birmingham, Alabama, United States

Location

Unknown Facility

Muscle Shoals, Alabama, United States

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Scottsboro, Alabama, United States

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Tucson, Arizona, United States

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Encino, California, United States

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Los Angeles, California, United States

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Sacramento, California, United States

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Spring Valley, California, United States

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Valley Village, California, United States

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Walnut Creek, California, United States

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Waterbury, Connecticut, United States

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Delray Beach, Florida, United States

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Hialeah, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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Ocala, Florida, United States

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Sandy Springs, Georgia, United States

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Chicago, Illinois, United States

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Indianapolis, Indiana, United States

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Erlanger, Kentucky, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Madisonville, Kentucky, United States

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Paducah, Kentucky, United States

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New Hyde Park, New York, United States

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Greensboro, North Carolina, United States

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Morehead City, North Carolina, United States

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Statesville, North Carolina, United States

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Cincinnati, Ohio, United States

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Marion, Ohio, United States

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Tulsa, Oklahoma, United States

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Eugene, Oregon, United States

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Portland, Oregon, United States

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Charleston, South Carolina, United States

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Greer, South Carolina, United States

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North Charleston, South Carolina, United States

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Bristol, Tennessee, United States

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Austin, Texas, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Manassas, Virginia, United States

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Richmond, Virginia, United States

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Bellevue, Washington, United States

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Olympia, Washington, United States

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Oregon, Wisconsin, United States

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Beroun, Czechia

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Brno, Czechia

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Ostrava, Czechia

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Pardubice, Czechia

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Prague, Czechia

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Velké Hoštice, Czechia

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Sátoraljaújhely, Hungary

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Szikszó, Hungary

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Eindhoven, Netherlands

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Groningen, Netherlands

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Arkhangelsk, Russia

Location

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Moscow, Russia

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Unknown Facility

Nizhny Novgorod, Russia

Location

Unknown Facility

Saint Petersburg, Russia

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Diabetes Mellitus

Interventions

diethyl 2-((3-dimethylcarbamoyl-4-((4'-trifluoromethylbiphenyl-2-carbonyl)amino)phenyl)acetyloxymethyl)-2-phenylmalonate

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 26, 2009

First Posted

June 29, 2009

Study Start

June 1, 2009

Primary Completion

May 1, 2010

Study Completion

July 1, 2010

Last Updated

February 4, 2013

Record last verified: 2013-01

Locations