Investigating Optical and Neural Causes of Vision Loss

NCT00926913 | Withdrawn

• 1 other identifier: C7002-R
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

With the aging of the population, the prevalence of age-related macular degeneration (AMD) eye disease has resulted in a large number of people suffering from central vision loss. In fact, the most prevalent cause of blindness among veterans is AMD. Since the number of elderly veterans is expected to double in the next 10 years, loss of vision due to AMD is also expected to proportionally and considerably escalate. People with impaired vision have difficulty with daily activities, such as, reading, driving, and recognizing faces. The goal of the research project is to provide information on factors that contribute to visual impairment. This knowledge is necessary for the development of innovative approaches that will optimize the benefit of vision rehabilitation techniques, aimed at improving vision, thus allowing our veterans to maintain function and productivity. The findings from the proposed research will benefit our veterans and all aging people.

Conditions

Macular Degeneration

Keywords

Macular Degeneration

Outcome Measures

Primary Outcomes (1)

• Ocular aberrations

  One time only

Study Arms (1)

Group 1

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Normal healthy subjects and patients diagnosed with age-related macular degeneration and central vision loss will participate in the study.

You may qualify if:

• qualification for entry into the study based on clinical evaluation,
• competence to understand and willingness to sign an informed consent form and participate in the study,
• pupils that dilate to 5 mm or more.
• corrected visual acuities better than 20/30,
• intraocular pressure less than 21 mm Hg,
• no family history of AMD,
• no history of ophthalmic surgery or neurologic disease,
• no history of diabetes, glaucoma, or a history of elevated intraocular pressure.
• The recruitment will ensure that approximately 40 subjects will fall into each of the three age groups, 50 to 60 years, 61 to 70 years, and 71 years and older. One eye of each subject will be selected at random to be included in the study.

You may not qualify if:

• Ocular opacities that preclude acquiring a clear fundus photograph or refractive errors greater than 4 diopters.

Sponsors & Collaborators

• US Department of Veterans Affairs: lead

Study Sites (1)

Jesse Brown VA Medical Center, Chicago, IL

Chicago, Illinois, 60612, United States

Location

MeSH Terms

Conditions

Macular Degeneration

Condition Hierarchy (Ancestors)

Retinal Degeneration; Retinal Diseases; Eye Diseases

Study Officials

• Mahnaz Shahidi, PhD

  Jesse Brown VA Medical Center, Chicago, IL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 22, 2009
• First Posted: June 24, 2009
• Study Start: December 1, 2014
• Primary Completion: March 1, 2015
• Study Completion: July 1, 2015
• Last Updated: April 6, 2015

Record last verified: 2015-04

Locations

US (1)