Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD
PAM
1 other identifier
observational
320
1 country
1
Brief Summary
Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2009
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 23, 2009
CompletedFirst Posted
Study publicly available on registry
June 24, 2009
CompletedStudy Start
First participant enrolled
July 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedJune 9, 2010
June 1, 2010
3.4 years
June 23, 2009
June 8, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD
24 months
Secondary Outcomes (5)
Distance acuity
24 months
Age
24 months
Smoking
24 months
Obesity
24 months
Lesion classification (AREDS)
24 months
Study Arms (1)
Dry AMD
male or female persons aged over 50 years with dry age-related macular degeneration
Interventions
Eligibility Criteria
male or female persons aged over 50 years with dry AMD
You may qualify if:
- Dry MD
- Age over 50 years
You may not qualify if:
- Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole)
- Prior vitrectomy or buckle surgery
- Uveitis posterior, multifocal chorioiditis
- Pathologic myopia
- Diabetic retinopathy
- Visualization of the macula not possible (dens cataract, vitreous haemorrhage)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery
Vienna, Vienna, 1030, Austria
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Susanne Binder, Prof MD
Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 23, 2009
First Posted
June 24, 2009
Study Start
July 1, 2009
Primary Completion
December 1, 2012
Study Completion
December 1, 2012
Last Updated
June 9, 2010
Record last verified: 2010-06