Investigation of Clinical Spectrum, Bacterial Pathogens and Immune Response in Acute Pharyngotonsillitis
Frequency, Pathogen Spectrum and Specific Immune Response in Acute Pharyngotonsillitis in Children and Adolescents
1 other identifier
observational
4,500
1 country
3
Brief Summary
Acute pharyngotonsillitis is one of the most common infections encountered by pediatricians. Most children with acute pharyngotonsillitis have symptoms that can be attributed to viral infection. However 30-40% of cases is of bacterial etiology. The purpose of this study is to examine frequency, age distribution, clinical picture and pathogen distribution in acute pharyngotonsillitis in children in a large urban setting.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2009
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2009
CompletedFirst Submitted
Initial submission to the registry
June 22, 2009
CompletedFirst Posted
Study publicly available on registry
June 23, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedSeptember 8, 2010
September 1, 2010
1.1 years
June 22, 2009
September 7, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The responsible pathogens (Frequency of GABHS) of acute pharyngotonsillitis and its clinical and serological response in children in a large urban setting.
1 year
Secondary Outcomes (1)
In a subset of patients the immune response to GABHS will be measured at beginning and after 7 and 28 days.
one month
Eligibility Criteria
Patients aged 3 months to 18 years who will present clinical signs of tonsillopharyngitis.
You may qualify if:
- age 3 months to 18 years
- clinical signs of tonsillopharyngitis
- informed consent
You may not qualify if:
- age more than 18 years
- diagnosed chronic disease or infection (e.x. HIV, tuberculosis, malignancy)
- current participation in another research projects that may interfere with this study
- Incapability to perform all study procedure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Paeditric office
Babenhausen, Hesse, 64832, Germany
Paediatric office
Dietzenbach, Hesse, 63128, Germany
Paediatric office
Offenbach-Rumpenheim, Hesse, 63075, Germany
Related Publications (3)
Shulman ST. Acute streptococcal pharyngitis in pediatric medicine: current issues in diagnosis and management. Paediatr Drugs. 2003;5 Suppl 1:13-23.
PMID: 14632102BACKGROUNDBrook I, Dohar JE. Management of group A beta-hemolytic streptococcal pharyngotonsillitis in children. J Fam Pract. 2006 Dec;55(12):S1-11; quiz S12.
PMID: 17137534BACKGROUNDNussinovitch M, Finkelstein Y, Amir J, Varsano I. Group A beta-hemolytic streptococcal pharyngitis in preschool children aged 3 months to 5 years. Clin Pediatr (Phila). 1999 Jun;38(6):357-60. doi: 10.1177/000992289903800606.
PMID: 10378093BACKGROUND
Biospecimen
throat culture, blood sample
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stefan Zielen, Prof.
Medaimun GmbH and Johann Wolfgang Goethe University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 22, 2009
First Posted
June 23, 2009
Study Start
May 1, 2009
Primary Completion
June 1, 2010
Study Completion
June 1, 2010
Last Updated
September 8, 2010
Record last verified: 2010-09