Automating Breast Radiation Therapy (RT)

NCT00923871 | Completed DMC

• 1 other identifier: UHN REB 09-0197-CE
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Breast radiation treatment is planned from a Computed Tomography (CT) scan. This study is designed to investigate a method to reduce the time between the planning of radiation treatment and its actual start by automating the intensity-modulated radiation therapy (IMRT) planning process. The investigators plan to examine data from another scan called Cone Beam Computed Tomography (CBCT). A CBCT scan provides similar information to a conventional CT scan, however the images for CBCT are acquired at the treatment unit (linear accelerator used for treatment). Using these x-ray pictures of patients, the study team consisting of a radiation oncologist, a medical physicist and a radiation therapist will create a custom treatment plan unique to each patient. By doing this, the investigators hope to reduce the amount of time spent waiting for treatment and the number of hospital visits for patients in the future.

Conditions

Breast Cancer

Keywords

CBCT; Breast Cancer

Outcome Measures

Primary Outcomes (1)

• To generate on-line IMRT treatment plans using automated tools based on CBCT images acquired at the treatment unit.

  3 years

Study Arms (1)

Cone Beam CT

EXPERIMENTAL

Procedure: Cone Beam CT

Interventions

Cone Beam CT PROCEDURE

Patients will also have a CBCT scan when they are having their first IMRT treatment.

Cone Beam CT

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with breast cancer who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.
• Patients with any stage of breast cancer.
• Patients with prior treatment such as surgery or chemotherapy for any type of cancer.
• Able to provide a written informed consent.
• years of age or older.

You may not qualify if:

• \< 18 years of age.
• Unable to provide informed consent.
• Males.
• Patients who received partial breast radiation and not the standard dose.
• Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions.

Sponsors & Collaborators

• University Health Network, Toronto: lead
• Princess Margaret Hospital, Canada: collaborator

Study Sites (1)

University Health Network, Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada

Location

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Anne Koch, MD

  University Health Network, Princess Margaret Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2009
• First Posted: June 18, 2009
• Study Start: June 1, 2009
• Primary Completion: January 5, 2015
• Study Completion: April 29, 2016
• Last Updated: October 18, 2022

Record last verified: 2022-10

Locations

CA (1)