Computerized Cognitive Skills Training for Adolescents With Velocardiofacial Syndrome

NCT00917189 | Completed DMC

• 2 other identifiers: R33MH085901DDTR B4-TBI
• Study Type: interventional
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

This study will test a computer-based treatment for youth with the genetic disorder velocardiofacial syndrome (VCFS) to help them improve skills in memory, attention, and executive functioning.

Conditions

Velocardiofacial Syndrome

Keywords

VCFS; Chromosome 22q Deletion Syndrome; Learning Disorders

Outcome Measures

Primary Outcomes (1)

• The California Learning Test and the Visual Span Test

  Measured immediately following the intervention at each phase

Secondary Outcomes (1)

• Performance on the Apartment Test

  Measured immediately following the intervention at each phase

Study Arms (1)

Computerized Cognitive Skills Training

EXPERIMENTAL

Participants will receive the Challenging Our Minds intervention, delivered in-person in Phase 1 and remotely in Phases 2 and 3.

Behavioral: Challenging Our Minds Program

Interventions

Challenging Our Minds Program BEHAVIORAL

A computerized cognitive intervention that provides training in attention, memory, and executive function

Computerized Cognitive Skills Training

Eligibility Criteria

• Age: 12 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Diagnosis of velocardiofacial syndrome (VCFS)
• IQ score between 70 and 90

You may not qualify if:

• Presence of psychotic symptoms

Sponsors & Collaborators

• State University of New York - Upstate Medical University: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

Location

Related Publications (2)

• Mariano MA, Tang K, Kurtz M, Kates WR. Examining the durability of a hybrid, remote and computer-based cognitive remediation intervention for adolescents with 22q11.2 deletion syndrome. Early Interv Psychiatry. 2018 Aug;12(4):686-693. doi: 10.1111/eip.12367. Epub 2016 Sep 15.

  PMID: 27629273 RESULT

• Mariano MA, Tang K, Kurtz M, Kates WR. Cognitive remediation for adolescents with 22q11 deletion syndrome (22q11DS): a preliminary study examining effectiveness, feasibility, and fidelity of a hybrid strategy, remote and computer-based intervention. Schizophr Res. 2015 Aug;166(1-3):283-9. doi: 10.1016/j.schres.2015.05.030. Epub 2015 Jun 1.

  PMID: 26044111 RESULT

MeSH Terms

Conditions

DiGeorge Syndrome; Learning Disabilities

Condition Hierarchy (Ancestors)

22q11 Deletion Syndrome; Craniofacial Abnormalities; Musculoskeletal Abnormalities; Musculoskeletal Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Lymphatic Abnormalities; Lymphatic Diseases; Hemic and Lymphatic Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn; Hypoparathyroidism; Parathyroid Diseases; Endocrine System Diseases; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Wendy R. Kates, PhD

  State University of New York - Upstate Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2009
• First Posted: June 10, 2009
• Study Start: September 1, 2009
• Primary Completion: April 1, 2015
• Study Completion: April 1, 2015
• Last Updated: October 21, 2016

Record last verified: 2016-10

Locations

US (1)