Clinical, Environmental, Neurocognitive, Brain Imaging, and Genetic Validity of Autism and ADHD

NCT00916851 | Completed DMC

• 1 other identifier: 200903062R
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The behavioral patterns, neurocognitive and social impairments, and high heritability are the common characteristics of autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD), the two most common early-onset neuropsychiatric disorders. Little is known about the discriminative validity between these two disorders. As brain imaging studies have been recognized as an important biological tool to validate disease involving the brain, no studies have employed this approach to distinguish the brain functioning between ASD and ADHD. Moreover, there is lack of comprehensive data of environmental, behavioral, neurocognitive, neuroimaging, and genetic data for healthy children. Hence, we propose this program project involving expertise researchers in the fields of child psychiatry and psychology, psychiatric genetics, and brain imaging studies to elucidate the neuropathophysiology and genes \& environment interactions of ASD and ADHD as comparing to healthy controls by integrating data from environments, behavioral phenotypes, endophenotypes, and genotypes in one study.

Conditions

Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder

Keywords

attention-deficit hyperactivity disorder; autism spectrum disorders; normally developing children and adolescents; cognitive functions; emotion/behaviors; brain imaging; genotypes

Study Arms (3)

Control group

Normally developing children and adolescents

ADHD group

Children and adolescents with ADHD

ASD group

Children and adolescents with ASD

Eligibility Criteria

• Age: 8 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This 3-year program project consists of three projects investigating a sample, aged 8-17 years, of 100 normally developing children and adolescents, 100 ADHD, and 100 ASD.

You may qualify if:

• Control group: Subjects without ADHD or ASD; ADHD group \& ASD group: subjects have a clinical diagnosis of ADHD, or ASD defined by the DSM-IV, which was made by a full-time board-certificated child psychiatrist at the first visit and following visits.
• Ages range from 7 to 18 when we conduct the study.
• Subjects have at least one biological parent.
• Both parents are Han Chinese.
• subjects and their biological parents (and siblings if any) consent to participate in this study for complete phenotype assessments and blood withdraw for genetic study

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

Location

Related Publications (3)

• Tsai CJ, Lin HY, Tseng IW, Gau SS. White matter microstructural integrity correlates of emotion dysregulation in children with ADHD: A diffusion imaging tractography study. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Aug 30;110:110325. doi: 10.1016/j.pnpbp.2021.110325. Epub 2021 Apr 20.

  PMID: 33857524 DERIVED

• Chiang HL, Chen YJ, Shang CY, Tseng WY, Gau SS. Different neural substrates for executive functions in youths with ADHD: a diffusion spectrum imaging tractography study. Psychol Med. 2016 Apr;46(6):1225-38. doi: 10.1017/S0033291715002767. Epub 2016 Jan 8.

  PMID: 26744120 DERIVED

• Chiang HL, Chen YJ, Lo YC, Tseng WY, Gau SS. Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/ hyperactivity disorder. J Psychiatry Neurosci. 2015 Sep;40(5):325-35. doi: 10.1503/jpn.140106.

  PMID: 25871496 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Behavior

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders; Child Development Disorders, Pervasive

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2009
• First Posted: June 10, 2009
• Study Start: August 1, 2010
• Primary Completion: July 31, 2013
• Study Completion: July 31, 2013
• Last Updated: September 2, 2021

Record last verified: 2021-09

Locations

TW (1)