Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

NCT00911677 | Completed

• 1 other identifier: OHREB 2004800-01H
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Conditions

Delirium; Postoperative Cognitive Dysfunction

Keywords

Delirium (MeSH Unique ID D003693); Cognition Disorders (MeSH Unique ID D003072); Postoperative Complications (MeSH Unique ID D011183); Apolipoproteins E (MeSH Unique ID D001057)

Outcome Measures

Primary Outcomes (1)

• Delirium as assessed by the Confusion Assessment Method

  7 days postoperatively

Secondary Outcomes (2)

• POCD as assessed by a battery of 9 neuropsychometric tests

  7 days postoperatively

• POCD as assessed by a battery of 9 neuropsychometric tests

  3 months postoperatively

Study Arms (1)

Open Aortic Repair

Patients 60 years of age and older undergoing open repair of the abdominal aorta

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients 60 years of age or greater undergoing open repair of the abdominal aorta at an academic tertiary care hospital.

You may qualify if:

• Age 60 or greater
• Open repair of the abdominal aorta

You may not qualify if:

• refusal;
• planned endovascular repair;
• emergency surgery;
• previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
• active alcohol or substance abuse; and
• physical inability to complete neuropsychometric testing.

Sponsors & Collaborators

• Ottawa Hospital Research Institute: lead
• Canadian Anesthesiologists' Society: collaborator
• University of Ottawa: collaborator

Study Sites (1)

The Ottawa Hospital - Civic Campus

Ottawa, Ontario, K1Y 4E9, Canada

Location

Related Publications (2)

• Bryson GL, Wyand A, Wozny D, Rees L, Taljaard M, Nathan H. A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair. Can J Anaesth. 2011 Mar;58(3):246-55. doi: 10.1007/s12630-010-9446-6. Epub 2011 Jan 11.

  PMID: 21222188 DERIVED

• Bryson GL, Wyand A, Wozny D, Rees L, Taljaard M, Nathan H. The clock drawing test is a poor screening tool for postoperative delirium and cognitive dysfunction after aortic repair. Can J Anaesth. 2011 Mar;58(3):267-74. doi: 10.1007/s12630-010-9448-4. Epub 2010 Dec 31.

  PMID: 21194015 DERIVED

MeSH Terms

Conditions

Delirium; Postoperative Cognitive Complications; Cognition Disorders; Postoperative Complications

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Pathologic Processes; Cognitive Dysfunction

Study Officials

• Gregory L Bryson, MD, FRCPC

  Department of Anesthesiology, The Ottawa Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 29, 2009
• First Posted: June 2, 2009
• Study Start: August 1, 2005
• Primary Completion: March 1, 2008
• Study Completion: May 1, 2009
• Last Updated: June 2, 2009

Record last verified: 2009-05

Locations

CA (1)