Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease

NCT00905294 | Terminated

• 1 other identifier: INFACTs 2009-001
• Study Type: observational
• Target: 11
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.

Conditions

Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels

  Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study

  change from baseline to after percutaneous coronary intervention

Study Arms (1)

coronary artery disease

Subjects with coronary artery disease undergoing percutaneous coronary intervention

Other: Blood draws

Interventions

Blood draws OTHER

Observational: blood draws only

coronary artery disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with coronary artery disease undergoing percutaneous coronary intervention

You may qualify if:

• Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA)
• Planned percutaneous coronary intervention during admission

You may not qualify if:

• Recent history (\< 6 months) of an acute coronary syndrome (other than current admission) or stroke
• Recent history (\< 6 months) of major surgery, trauma or thromboembolic event
• Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months
• Current evidence of infection

Sponsors & Collaborators

• University College Cork: lead
• Royal College of Surgeons, Ireland: collaborator

Study Sites (2)

Cork University Hospital

Cork, Ireland

Location

Beaumont Hospital

Dublin, Ireland

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum, plasma

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Noel M. Caplice, M.D, Ph.D.

  University College Cork, Ireland

  PRINCIPAL INVESTIGATOR

• Dermot Kenny, M.D.

  Royal College Surgeons in Ireland

  STUDY DIRECTOR

• David Foley, M.B.

  Beaumont Hospital, Dublin, Ireland

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Cardiovascular Sciences

Study Record Dates

• First Submitted: May 19, 2009
• First Posted: May 20, 2009
• Study Start: August 1, 2009
• Primary Completion: August 1, 2010
• Study Completion: August 1, 2010
• Last Updated: June 19, 2013

Record last verified: 2013-06

Locations

IE (2)