Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants

NCT00904774 | Unknown

• 1 other identifier: AOR 07 018
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:

1. 1.a genome-wide association (GWA) study in VLBW neonates,
2. 2.a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
3. 3.functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).

Conditions

Bronchopulmonary Dysplasia

Keywords

bronchopulmonary dysplasia; neonates; lung development; prematurity

Outcome Measures

Primary Outcomes (1)

• bronchopulmonary dysplasia

  36 weeks of postconceptional age

Study Arms (1)

premature neonates

gestational age less than 28 weeks

Eligibility Criteria

• Age: Up to 8 Weeks
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Premature neonates

You may qualify if:

• Gestational age \< 28 weeks
• Inborn birth
• Prophylactic administration of surfactant in the delivery room
• Written informed consent obtained from parents

You may not qualify if:

• Gestational age of 28 weeks or more
• Outborn birth
• No prophylactic administration of surfactant in the delivery room
• Congenital malformation
• Absence of written informed consent obtained from parents

Sponsors & Collaborators

• Centre Hospitalier Intercommunal Creteil: lead

Study Sites (1)

Centre Hospitalier Intercommunal

Créteil, 94000, France

Location

Related Publications (1)

• Hadchouel A, Decobert F, Franco-Montoya ML, Halphen I, Jarreau PH, Boucherat O, Martin E, Benachi A, Amselem S, Bourbon J, Danan C, Delacourt C. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS One. 2008 Sep 11;3(9):e3188. doi: 10.1371/journal.pone.0003188.

  PMID: 18784838 BACKGROUND

Related Links

• The french PremUp Foundation is dedicated to pregnancy and the newborn

MeSH Terms

Conditions

Bronchopulmonary Dysplasia; Premature Birth

Condition Hierarchy (Ancestors)

Ventilator-Induced Lung Injury; Lung Injury; Lung Diseases; Respiratory Tract Diseases; Infant, Premature, Diseases; Infant, Newborn, Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 19, 2009
• First Posted: May 20, 2009
• Study Start: May 1, 2009
• Last Updated: May 20, 2009

Record last verified: 2009-05

Locations

FR (1)