Biomarkers for Early Detection of Lung Cancer in Patients With Lung Cancer, Participants at High-Risk for Developing Lung Cancer, or Healthy Volunteers

NCT00899262 | Unknown

• 4 other identifiers: CDR0000599372SWWCI-MEDLUNGUKCRN-4682EU-20862
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 2

Brief Summary

RATIONALE: Collecting and storing samples of sputum and tissue to study in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking samples of sputum and tissue from lung cancer patients, participants at high risk for developing lung cancer, and from healthy volunteers (both smokers and non-smokers).

Conditions

Lung Cancer; Tobacco Use Disorder

Keywords

lung cancer; tobacco use disorder

Outcome Measures

Primary Outcomes (2)

• Development of a cost-effective, high-throughput, and non-invasive screening test using Fourier transform infrared technology for detection of early lung cancer in sputum of high-risk people

• Discovery and characterization of novel metabolic biomarkers in sputum samples that permit detection of lung cancer at pre-cancerous and early lung cancer stages

Interventions

immunohistochemistry staining method OTHER

laboratory biomarker analysis OTHER

sputum cytology OTHER

Fourier transform infrared spectroscopy PROCEDURE

diagnostic bronchoscopy PROCEDURE

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Diagnosis of lung cancer * At high risk for developing lung cancer * Non-high-risk smoking or non-smoking volunteer (control) PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• South West Wales Cancer Institute: lead

Study Sites (2)

Prince Philip Hospital

Llanelli, Wales, SA14 8QF, United Kingdom

RECRUITING

South West Wales Cancer Institute

Swansea, Wales, SA2 8PP, United Kingdom

RECRUITING

Related Publications (1)

• Lewis PD, Lewis KE, Ghosal R, Bayliss S, Lloyd AJ, Wills J, Godfrey R, Kloer P, Mur LA. Evaluation of FTIR spectroscopy as a diagnostic tool for lung cancer using sputum. BMC Cancer. 2010 Nov 23;10:640. doi: 10.1186/1471-2407-10-640.

  PMID: 21092279 RESULT

MeSH Terms

Conditions

Lung Neoplasms; Tobacco Use Disorder

Interventions

Immunohistochemistry; Spectroscopy, Fourier Transform Infrared

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Histocytochemistry; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Histological Techniques; Investigative Techniques; Immunologic Techniques; Spectrophotometry, Infrared; Spectrophotometry; Photometry; Chemistry Techniques, Analytical; Spectrum Analysis

Study Officials

• Paul D. Lewis, BSc, PhD

  Swansea University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: April 1, 2008
• Primary Completion: April 1, 2011
• Last Updated: August 26, 2013

Record last verified: 2009-06

Locations

GB (2)