Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer

NCT00899210 | Completed

• 3 other identifiers: CDR0000574192CHUG-METALLO-1RECF0455
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research trial is studying matrix metalloproteinases after surgery or radiofrequency ablation in patients with liver metastases from colorectal cancer.

Conditions

Colorectal Cancer; Metastatic Cancer

Keywords

liver metastases; adenocarcinoma of the colon; stage IV colon cancer; adenocarcinoma of the rectum; stage IV rectal cancer; recurrent colon cancer; recurrent rectal cancer

Outcome Measures

Primary Outcomes (1)

• Kinetics of postoperative changes of serum matrix metalloproteinases (MMP) and their inhibitors (TIMP)

Secondary Outcomes (4)

• Predictive value of postoperative risk of recurrence

• Correlation of risk of recurrence with surgical technique

• Elevated serum levels of MMP vs carcinoembryonic antigen as a marker of hepatic or extrahepatic recurrence

• Correlation of postoperative serum HGF/SF with plasma levels in MMPs

Interventions

laboratory biomarker analysis OTHER

cryosurgery PROCEDURE

radiofrequency ablation PROCEDURE

therapeutic conventional surgery PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Patients with histologically confirmed adenocarcinoma of the colon or rectum and liver metastases * Must have undergone prior complete resection of the tumor more than 3 months ago * Liver metastases must be resectable or accessible for radiofrequency ablation * Patients undergoing cryosurgery of the digestive tract for a reason other than cancer or infection (control) PATIENT CHARACTERISTICS: * No other neoplastic disease that is measurable or being treated other than colorectal cancer * No heart failure or severe respiratory disease * No uncontrolled infection or other severe disease PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No participation in another study involving new drugs

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University Hospital, Grenoble: lead

MeSH Terms

Conditions

Colorectal Neoplasms; Neoplasm Metastasis; Colonic Neoplasms; Rectal Neoplasms

Interventions

Cryosurgery; Radiofrequency Ablation

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ablation Techniques; Surgical Procedures, Operative; Radiofrequency Therapy; Therapeutics

Study Officials

• Christine Rebischung

  University Hospital, Grenoble

  STUDY CHAIR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: September 1, 2003
• Primary Completion: May 1, 2011
• Last Updated: May 17, 2011

Record last verified: 2011-05