NCT00897559

Brief Summary

RATIONALE: Studying the genes expressed in samples of bone marrow from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking at bone marrow samples from patients with acute leukemia.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2008

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 3, 2008

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

May 9, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 12, 2009

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 11, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 11, 2009

Completed
Last Updated

May 17, 2017

Status Verified

May 1, 2017

Enrollment Period

1.4 years

First QC Date

May 9, 2009

Last Update Submit

May 16, 2017

Conditions

Leukemia

Keywords

adult acute megakaryoblastic leukemia (M7)

Outcome Measures

Primary Outcomes (1)

  • Correlation of gene mutations with adult acute megakaryoblastic leukemia (AMKL)

    1 year

Interventions

gene expression analysisGENETIC
mutation analysisGENETIC
polymorphism analysisGENETIC
protein analysisGENETIC
flow cytometryOTHER
laboratory biomarker analysisOTHER

Eligibility Criteria

Age18 Years - 120 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with Acute Leukemia

DISEASE CHARACTERISTICS: * Diagnosis of adult acute megakaryoblastic leukemia * Archived bone marrow specimens from the ECOG tissue repository PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

LeukemiaLeukemia, Megakaryoblastic, Acute

Interventions

Gene Expression ProfilingAmplified Fragment Length Polymorphism AnalysisFlow Cytometry

Condition Hierarchy (Ancestors)

Neoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLeukemia, Myeloid, AcuteLeukemia, Myeloid

Intervention Hierarchy (Ancestors)

Genetic TechniquesInvestigative TechniquesDNA FingerprintingPolymerase Chain ReactionNucleic Acid Amplification TechniquesCell SeparationCytological TechniquesClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisCytophotometryFluorometryLuminescent MeasurementsPhotometryChemistry Techniques, Analytical

Study Officials

  • John Crispino, PhD

    Robert H. Lurie Cancer Center

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2009

First Posted

May 12, 2009

Study Start

July 3, 2008

Primary Completion

November 11, 2009

Study Completion

November 11, 2009

Last Updated

May 17, 2017

Record last verified: 2017-05

Data Sharing

IPD Sharing
Will not share

Data sharing is dictated by the group's data sharing plan.