Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

NCT00897468 | Completed

• 3 other identifiers: VICC BRE 0704P30CA068485VU-VICC-BRE-0704
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.

Conditions

Breast Cancer

Keywords

breast cancer

Outcome Measures

Primary Outcomes (2)

• Development of new in vivo models of human breast cancer

  1 year

• Correlation of response in this model to actual treatment outcome in patients, if the in vivo model proven feasible

  5 years

Study Arms (1)

breast cancer patients

Other: laboratory biomarker analysis; Other: medical chart review

Interventions

laboratory biomarker analysis OTHER

Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.

breast cancer patients

medical chart review OTHER

patient chart review will occur in conjunction with patient data collection for final analyses.

breast cancer patients

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

breast cancer patients

DISEASE CHARACTERISTICS: * Diagnosis of breast cancer * Any stage of disease * Primary or metastatic disease * Human breast tumor tissues available after the diagnoses have been made * Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103 * Have consented to the use of their tissues for research purpose * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Vanderbilt-Ingram Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232-6838, United States

Location

Related Links

• Vanderbilt-Ingram Cancer Center, Find a Clinical Trial

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• A. Bapsi Chakravarthy, MD

  Vanderbilt-Ingram Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor; Radiation Oncologist

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: February 1, 2007
• Primary Completion: May 1, 2018
• Study Completion: May 1, 2018
• Last Updated: May 4, 2018

Record last verified: 2018-05

Locations

US (1)