The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
1 other identifier
interventional
N/A
1 country
1
Brief Summary
Cystoids macular edema (CME) is one of the most common causes of low vision due to uveitis. The treatment for reducing the intra-ocular inflammation can decrease the macular edema. In some patients, CME persists even after inflammation control, and additional treatment is needed for better vision. Oral steroid, periocular and intravitreal Triamcinolone are the principles in treatment, but some complications like cataracts and increased ocular pressure have been seen. Diclophenac is a non-steroid anti-inflammatory drug that improves the vision and decreases the macular thickness by slowing down the prostaglandin E2 (PGE2) ending in vascular endothelial growth factor (VEGF) inhibition. In this study, the investigators are going to compare the therapeutic affect of intravitreal Diclophenac and Triamcinolone in persistent uveitic cystoids macular edema. Since diclophenac is a cheap and accessible drug in all curative centers it could be applied instead of Triamcinolone.
Trial Health
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 4, 2009
CompletedFirst Posted
Study publicly available on registry
May 6, 2009
CompletedMay 6, 2009
May 1, 2009
May 4, 2009
May 4, 2009
Conditions
Study Arms (2)
Diclophenac
EXPERIMENTALTriamcinolone
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- cystoids macular edema which is diagnosed by OCT and flurocein angiography
- /200 \< Visual acuity \< 20/50
- resistance to routine treatment (oral treatment, periocular injection)
You may not qualify if:
- history of retinal disease cause macular edema like diabetes
- arterial occlusion
- monocular patients
- patients candidate for intra-ocular operation
- history of glaucoma or ocular hypertension
- any cataract that would interfere with OCT
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ophthalmic Research Center
Tehran, Tehran Province, 166666, Iran
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 4, 2009
First Posted
May 6, 2009
Last Updated
May 6, 2009
Record last verified: 2009-05