Post Traumatic Stress Disorder and Neural Mechanisms Involved in Its Treatment

NCT00893568 | Completed

• 2 other identifiers: 2009/012009-A00193-54
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

The post traumatic stress disorder PTSD arises when the physiological response to stress does not come to its term. This study aims to explore the cognitive, psycho physiological and cerebral mechanisms involved in PTSD, in fear conditioning and face matching tasks, before and after treatment.PTSD patients will be recruited by Pr Jean-Claude Samuelian in his service at the Conception Hospital and by Pr Jean-Michel Azorin in his service at the Sainte Marguerite Hospital (Marseille) and will undergo either CBT or EMDR within those same services. The tasks they will be asked to perform will study the psycho physiological, cognitive and central mechanisms involved in PTSD and its treatment. All in all, 17 healthy controls will be recruited as well as 17 PTSD patients for each of the two treatment group.In terms of perspectives, this study would help isolate neural systems functionally involved in PTSD and its treatment. A better knowledge of those mechanisms would set room for the optimization of the current PTSD treatment.

Conditions

Post Traumatic Stress Disorders

Keywords

Post traumatic stress disorder PTSD

Outcome Measures

Primary Outcomes (1)

• To verify the hypothesis of a levying of inhibition of the CPFm on the tonsil, in the PTSD

  3 years

Secondary Outcomes (1)

• Studies of the peripheral, cognitive and central mechanisms, before, then 1 week and 6 months after treatment by CBT or EMDR

  3 years

Study Arms (3)

Healthy volunteers

ACTIVE COMPARATOR

Healthy volunteers without treatment

Other: resonance magnetic imaging (fMRI),

CBT

EXPERIMENTAL

Psychotraumatized patients treated by Cognitive and Behavioral Therapies (CBT)

Other: resonance magnetic imaging (fMRI),

EMDR

EXPERIMENTAL

Psychotraumatized patients treated by Eye Movement Desensitization and Reprocessing (EMDR)

Other: resonance magnetic imaging (fMRI),

Interventions

resonance magnetic imaging (fMRI), OTHER

a cerebral study will be performed at the neuroanatomic and functional levels by resonance magnetic imaging (fMRI) realized in three times (before, one week and six months after treatment)

CBT; EMDR; Healthy volunteers

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• French speakers
• Not hospitalized grown-up patients suffering from a post-traumatic stress disorder ( PTSD) connected to one event.
• Subjects Controls: grown-up, mated with the patients in age (18 - 50 years; 4 years maximum of difference of age between a patient and his control), in sex and educational level (schooling of the 3rd level, at the level Bac+8; 3 years maximum of difference of educational level between a patient and his control)

You may not qualify if:

• Pregnancy
• Feeding
• Nobody under guardianship and grown-up persons being the object of a legal protective measure or not able to express their assent
• Alcoholic or addicted to drugs (including medicines)
• Other neurological disorders or psychiatric that post-traumatic stress disorder (for patients)
• Claustrophobia and contraindications in the IRMf
• Subjects controls, no known psychiatric or neurological pathology, as well as no psychiatric history.
• Persons private of freedom by a court or administrative order, persons hospitalized without assent
• Unability to read French

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique-Hopitaux de Marseille

Marseille, France

Location

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic; Combat Disorders

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2009
• First Posted: May 6, 2009
• Study Start: April 1, 2009
• Primary Completion: May 1, 2012
• Last Updated: August 28, 2014

Record last verified: 2014-08

Locations

FR (1)