Global Longitudinal Peak Systolic Strain (GLPSS) Derived From Transesophageal Echocardiography - A Reliable Measure of Systolic Function?

NCT00877565 | Unknown

• 1 other identifier: VI_echo_01_2009
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Systolic function is a substantial determinant of overall hemodynamics and organ function. Therefore assessment of left ventricular systolic function (LVF) has been of central interest in Echocardiography. Ejection fraction (EF) measurement has been the gold standard echo-derived measure to describe LVF. However, EF is a blood pool derived and therefore load dependent measure. Global longitudinal peak systolic strain average is a new parameter derived from speckle tracking tachnique. As a primarily myocardial deformation parameter it is considered to be an equivalent to EF measurement, but maybe less load dependend. The aim of the study is to investigate the reliability of GLPSS average to quantify LVF in the perioperative setting (in cardiac and non-cardiac cases).

Conditions

Surgery

Keywords

LVF; Left ventricular systolic function

Outcome Measures

Primary Outcomes (1)

• multivariate regression-analysis

  1, 5 years

Eligibility Criteria

• Age: 19 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients undergoing cardiac and non-cardiac surgery

You may qualify if:

• Adult patients in the age from 19-90 years
• Cardiac and non-cardiac surgery, where intubation is indicated
• Surgical procedures with a minimum duration of 30 min
• Elective cardiac surgery on patients scheduled for correction of:
• coronary artery disease with and without previous myocardial infarction
• dilated cardiomyopathy; HOCM
• disorders of the atrial or ventricular septum
• disorders of the aortic root or the aorta
• left and right heart valvular disease including stenotic and/or regurgitant valvular diseases.

You may not qualify if:

• No patient´s consent
• Contraindications for TEE (esophageal-, gastric disorders, haematologic disorders with increased bleeding incidence; ENT-surgery, surgery of the esophageus or stomach)
• Contraindications for positioning (e.g. clinical signs of acute lung edema/acute failing left or right heart, acute coronary syndrome, myocardial infarction in recent history = within 2 weeks prior to operation date)

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Clin. Dept. of Cardiothoracic and Vascular Anaesthesia and Intensive Medicine, Medical University of Vienna

Vienna, 1090, Austria

RECRUITING

Central Study Contacts

Heinz D Tschernich, M.D.

CONTACT

+43140400; heinz.tschernich@meduniwien.ac.at

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 7, 2009
• First Posted: April 8, 2009
• Study Start: February 1, 2009
• Last Updated: April 8, 2009

Record last verified: 2009-04

Locations

AU (1)