Jugular Venous Oxygen Saturation During Therapeutic Hypothermia After Cardiac Arrest

NCT00870610 | Completed

• 1 other identifier: 2010
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to understand what happens to cerebral metabolism during therapeutic hypothermia for hypoxic brain injury following cardiac arrest.

Conditions

Hypoxic Brain Injury; Hypothermia

Keywords

jugular venous oxygen saturation; hypothermia

Interventions

retrograde jugular venous cannulation PROCEDURE

Retrograde cannulation of jugular vein and intermittent sampling of venous blood from cerebral circulation before, during and after hypothermia.

Also known as: SjO2, cerebrovenous oxygen saturation

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who are in coma after cardiac arrest, admitted to the Intensive Care Unit of a University Teaching Hospital and undergoing therapeutic hypothermia

You may qualify if:

• Adult patients in coma after cardiac arrest undergoing therapeutic hypothermia

You may not qualify if:

• Age \< 18
• Pregnancy
• Traumatic brain injury
• Contraindications to cannulation as severe coagulopathy

Sponsors & Collaborators

• Policlinico Hospital: lead

Study Sites (1)

Intensive Care Unit-Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena

Milan, 20122, Italy

Location

Related Publications (3)

• Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW, Kloeck WG, Billi J, Bottiger BW, Morley PT, Nolan JP, Okada K, Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Hickey RW, Carli P, Vanden Hoek TL, Atkins D; International Liaison Committee on Resuscitation. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation. 2003 Jul 8;108(1):118-21. doi: 10.1161/01.CIR.0000079019.02601.90. No abstract available.

  PMID: 12847056 BACKGROUND

• Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002 Feb 21;346(8):557-63. doi: 10.1056/NEJMoa003289.

  PMID: 11856794 BACKGROUND

• Macmillan CS, Andrews PJ. Cerebrovenous oxygen saturation monitoring: practical considerations and clinical relevance. Intensive Care Med. 2000 Aug;26(8):1028-36. doi: 10.1007/s001340051315.

  PMID: 11030158 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Hypoxia, Brain; Hypothermia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Temperature Changes

Study Officials

• Davide Chiumello, MD

  Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: March 10, 2009
• First Posted: March 27, 2009
• Study Start: November 1, 2011
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: April 28, 2015

Record last verified: 2015-04

Locations

IT (1)