Flow Proportional Pressure Support in Volunteers

NCT00866541 | Unknown

• 1 other identifier: 327/07
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Flow proportional pressure support (FPPS) is a new mode of spontaneous breathing assistance. In patients with increased respiratory resistance the role of FPPS in comparison with the pressure support assist breathing mode is still unclear. In this study the investigators evaluate objective and subjective measured data in healthy volunteers with artificial increased resistance and FPPS breathing assistance.

Conditions

Healthy

Keywords

resistance; flow proportional pressure support; pressure support ventilation; volunteers; assistant breathing; breathing comfort and objective breathing data

Outcome Measures

Primary Outcomes (1)

• pressure support

  3 years

Study Arms (1)

volunteers

EXPERIMENTAL

artificial increased respiratory resistance

Device: artificial increased resistance (flow proportional pressure support)

Interventions

artificial increased resistance (flow proportional pressure support) DEVICE

respiratory resistance is increased by interpose of an artificial resistance tool in the in- and expiratory airways of the mechanical respirator

volunteers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age over 18 years
• ASA I and II

You may not qualify if:

• refusal of written informed consent
• chronic respiratory or cardiac diseases

Sponsors & Collaborators

• University Hospital Freiburg: lead

Study Sites (1)

University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany

RECRUITING

Related Publications (4)

• Mols G, Vetter T, Haberthur C, Geiger K, Guttmann J. Breathing pattern and perception at different levels of volume assist and pressure support in volunteers. Crit Care Med. 2001 May;29(5):982-8. doi: 10.1097/00003246-200105000-00018.

  PMID: 11378608 BACKGROUND

• Mols G, von Ungern-Sternberg B, Rohr E, Haberthur C, Geiger K, Guttmann J. Respiratory comfort and breathing pattern during volume proportional assist ventilation and pressure support ventilation: a study on volunteers with artificially reduced compliance. Crit Care Med. 2000 Jun;28(6):1940-6. doi: 10.1097/00003246-200006000-00042.

  PMID: 10890645 BACKGROUND

• Mols G, Rohr E, Benzing A, Haberthur C, Geiger K, Guttmann J. Breathing pattern associated with respiratory comfort during automatic tube compensation and pressure support ventilation in normal subjects. Acta Anaesthesiol Scand. 2000 Mar;44(3):223-30. doi: 10.1034/j.1399-6576.2000.440302.x.

  PMID: 10714832 BACKGROUND

• Guttmann J, Bernhard H, Mols G, Benzing A, Hofmann P, Haberthur C, Zappe D, Fabry B, Geiger K. Respiratory comfort of automatic tube compensation and inspiratory pressure support in conscious humans. Intensive Care Med. 1997 Nov;23(11):1119-24. doi: 10.1007/s001340050467.

  PMID: 9434916 BACKGROUND

Study Officials

• Daniel Steinmann, MD

  University Medical Center Freiburg

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Daniel Steinmann, MD

CONTACT

0049 761 270 2329; daniel.steinmann@uniklinik-freiburg.de

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 19, 2009
• First Posted: March 20, 2009
• Study Start: January 1, 2009
• Primary Completion: December 1, 2009
• Last Updated: March 20, 2009

Record last verified: 2009-03

Locations

DE (1)