Immunohistochemical Expression Patterns of microRNA Processing Enzyme Dicer in Cutaneous Malignant Melanoma, Benign and Dysplastic Melanocytic Naevi

NCT00862914 | Completed

• 1 other identifier: 006
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the researchers investigate the immunohistochemical distribution of Dicer in benign and dysplastic melanocytic naevi as well as in cutaneous malignant melanoma compared to intraindividual healthy control.

Conditions

Naevi; Malignant Melanoma

Keywords

Skin; MicroRNA; miRNA; Dicer; Malignant Melanoma

Study Arms (3)

1

benign melanocytic naevi

2

dysplastic melanocytic naevi

3

cutaneous malignant melanoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

dermatologic primary care clinic

You may qualify if:

• Patients with benign melanocytic naevi, dysplastic melanocytic naevi and cutaneous malignant melanoma.

You may not qualify if:

• Patients under 18 years of age
• Patients with other forms of cancer in previous medical history
• Pregnancy

Sponsors & Collaborators

• Ruhr University of Bochum: lead

Study Sites (1)

Department of Dermatology and Allergology, Ruhr-University Bochum

Bochum, North Rhine-Westphalia, 44791, Germany

Location

Related Publications (1)

• Sand M, Gambichler T, Sand D, Altmeyer P, Stuecker M, Bechara FG. Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi. Eur J Dermatol. 2011 Jan-Feb;21(1):18-21. doi: 10.1684/ejd.2011.1210.

  PMID: 21262599 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Paraffin embedded melanocytic skin lesion

MeSH Terms

Conditions

Nevus; Melanoma; Rhabdomyosarcoma, Embryonal, 2

Condition Hierarchy (Ancestors)

Nevi and Melanomas; Neoplasms by Histologic Type; Neoplasms; Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Skin Neoplasms; Neoplasms by Site; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Prof. Dr. Peter Altmeyer

  Department of Dermatology and Allergology, Ruhr-University Bochum

  PRINCIPAL INVESTIGATOR

• PD Dr. Falk G. Bechara

  Department of Dermatology and Allergology, Ruhr-University Bochum

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: March 16, 2009
• First Posted: March 17, 2009
• Study Start: July 1, 2008
• Primary Completion: February 1, 2009
• Study Completion: March 1, 2009
• Last Updated: October 16, 2012

Record last verified: 2012-10

Locations

DE (1)