NCT00860327|Terminated
Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects
Excitation-contraction Coupling in Human Ventricle Development
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Excitation-contraction Coupling in Human Ventricle Development
Sponsor study identifier
Secondary identifiers
NIH
observational
375
1 country
1
Study Start
December 2007
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2016
Actual (reported)Study Completion
June 2016
Actual (reported)Children who are born with heart defects undergo surgery when they are infants to correct the defects. However, many treatments that are used in pediatric heart patients were originally developed for adults and may not be the best option for children. This study will analyze tissue samples from newborns and infants undergoing surgery for heart defects to learn more about how a child's heart develops during the first year of life. This information may help to identify possible treatments geared specifically for the pediatric heart patient.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2016
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 2007
Date type not reportedThis date has not been verified as actual or estimated.
March 10, 2009
Actual (reported)March 12, 2009
Actual (reported)June 2016
Actual (reported)June 2016
Actual (reported)Calcium handling assay
Calcium handling will be assayed in tissue or cells by patch clamp, imaging or protein level measurement and will be done at the time the tissue is obtained.
At time of aquisition
Newborns with hypoplastic left heart syndrome who are receiving a right ventricle to pulmonary artery shunt as first stage palliation.
Infants who are undergoing complete repair for tetralogy of Fallot or similar pathology.
Children undergoing surgery for repair of congenital heart defects.
Emory University, Department of Pediatrics
Atlanta, Georgia, 30322, United States
Wiegerinck RF, Cojoc A, Zeidenweber CM, Ding G, Shen M, Joyner RW, Fernandez JD, Kanter KR, Kirshbom PM, Kogon BE, Wagner MB. Force frequency relationship of the human ventricle increases during early postnatal development. Pediatr Res. 2009 Apr;65(4):414-9. doi: 10.1203/PDR.0b013e318199093c.
Ventricular tissue, that would have been discarded, and was removed during surgery as part of the necessary repair for congenital heart defects
Mary B. Wagner, PhD
Emory University
375 participants (actual enrollment reported by the registry).
First Submitted
March 10, 2009
First Posted
March 12, 2009
Study Start
December 2007
Date type not reportedThis date has not been verified as actual or estimated.
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients
Contact the study team to confirm eligibility.
Primary Completion
June 2016
Actual (reported)Study Completion
June 2016
Actual (reported)Last Updated
August 22, 2016
Record last verified: 2016-08
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Source: ClinicalTrials.gov.
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