NCT00849914|Completed
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Sponsor study identifier
observational
28
1 country
1
Study Start
July 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2009
Actual (reported)Study Completion
February 2009
Actual (reported)MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2009
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2008
Date type not reportedThis date has not been verified as actual or estimated.
February 2009
Actual (reported)February 2009
Actual (reported)February 20, 2009
Actual (reported)February 24, 2009
Actual (reported)Patients with actinic keratoses of the skin
Patients with basal cell carcinoma of the skin
Patients with squamous cell carcinoma of the skin
dermatologic primary care clinic
Department of Dermatology and Allergology, Ruhr-University Bochum
Bochum, 44791, Germany
Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, Bechara FG. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010 Jul;28(6):649-53. doi: 10.3109/07357901003630918.
Punch biopsy from tumour, punch biopsy from healthy skin
Prof. Dr. Peter Altmeyer
Department of Dermatology and Allergology, Ruhr-University Bochum
28 participants (actual enrollment reported by the registry).
First Submitted
February 20, 2009
First Posted
February 24, 2009
Study Start
July 2008
Date type not reportedThis date has not been verified as actual or estimated.
Skin Cancer in Swiss Transplant Cohort Study
Contact the study team to confirm eligibility.
Primary Completion
February 2009
Actual (reported)Study Completion
February 2009
Actual (reported)Last Updated
October 16, 2012
Record last verified: 2012-10
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Source: ClinicalTrials.gov.
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