NCT00843271

Brief Summary

The purpose of the MESA Lung Study is to assess the role of endothelial dysfunction and genetic susceptibility to subclinical COPD and emphysema.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,359

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Oct 2004

Longer than P75 for all trials

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress98%
Oct 2004Jan 2027

Study Start

First participant enrolled

October 1, 2004

Completed
4.4 years until next milestone

First Submitted

Initial submission to the registry

February 12, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 13, 2009

Completed
17.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

April 23, 2026

Status Verified

April 1, 2026

Enrollment Period

22.3 years

First QC Date

February 12, 2009

Last Update Submit

April 17, 2026

Conditions

Chronic Obstructive Pulmonary Disease (COPD)EmphysemaEndothelial Dysfunction

Keywords

COPD MESA LUNG BIOMARKERS

Outcome Measures

Primary Outcomes (1)

  • Lung Function (FEV1 (L), FEV1/FVC (%))

    Up to 13 years

Secondary Outcomes (1)

  • Lung Density/Percent emphysema on CT (%)

    Up to 13 years

Study Arms (1)

MESA Lung

MESA-Lung is an ancillary study of the Multi-Ethnic Study of Atherosclerosis (MESA). MESA, established in 1999, is well characterized, multi-ethnic (white, Black, Hispanic and Chinese), and multi-center (Columbia, Johns Hopkins, Northwestern, UCLA, Minnesota,and Wake Forest) prospective cohort study. MESA-Lung included a 60% random sample of the MESA cohort at the six Field Centers in Exam 3 and Exam 4, stratified on race/ethnicity.

Eligibility Criteria

Age45 Years - 84 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

MESA cohort

You may qualify if:

  • A random sample of MESA participants active at Exam 3 and/or 4.

You may not qualify if:

  • MESA participants without MESA Exam 3 or 4 measurements.
  • MESA participants without FMD measurements in Exam 1.
  • MESA participants who have not consented to genetic testing.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (13)

  • He K, Liu K, Daviglus ML, Mayer-Davis E, Jenny NS, Jiang R, Ouyang P, Steffen LM, Siscovick D, Wu C, Barr RG, Tsai M, Burke GL. Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis. Am J Clin Nutr. 2008 Oct;88(4):1111-8. doi: 10.1093/ajcn/88.4.1111.

    PMID: 18842801RESULT

  • Jiang R, Burke GL, Enright PL, Newman AB, Margolis HG, Cushman M, Tracy RP, Wang Y, Kronmal RA, Barr RG. Inflammatory markers and longitudinal lung function decline in the elderly. Am J Epidemiol. 2008 Sep 15;168(6):602-10. doi: 10.1093/aje/kwn174. Epub 2008 Aug 6.

    PMID: 18687665RESULT

  • Mesia-Vela S, Yeh CC, Austin JH, Dounel M, Powell CA, Reeves A, Santella RM, Stevenson L, Yankelevitz D, Barr RG. Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers. Biomarkers. 2008 Jun;13(4):422-34. doi: 10.1080/13547500802002859.

    PMID: 18484356RESULT

  • Jiang R, Camargo CA Jr, Varraso R, Paik DC, Willett WC, Barr RG. Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr. 2008 Apr;87(4):1002-8. doi: 10.1093/ajcn/87.4.1002.

    PMID: 18400725RESULT

  • Barr RG, Stemple KJ, Mesia-Vela S, Basner RC, Derk SJ, Henneberger PK, Milton DK, Taveras B. Reproducibility and validity of a handheld spirometer. Respir Care. 2008 Apr;53(4):433-41.

    PMID: 18364054RESULT

  • Arehart E, Stitham J, Asselbergs FW, Douville K, MacKenzie T, Fetalvero KM, Gleim S, Kasza Z, Rao Y, Martel L, Segel S, Robb J, Kaplan A, Simons M, Powell RJ, Moore JH, Rimm EB, Martin KA, Hwa J. Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res. 2008 Apr 25;102(8):986-93. doi: 10.1161/CIRCRESAHA.107.165936. Epub 2008 Mar 6.

    PMID: 18323528RESULT

  • Lederer DJ, Benn EK, Barr RG, Wilt JS, Reilly G, Sonett JR, Arcasoy SM, Kawut SM. Racial differences in waiting list outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Feb 15;177(4):450-4. doi: 10.1164/rccm.200708-1260OC. Epub 2007 Nov 15.

    PMID: 18006881RESULT

  • Barr RG, Mesia-Vela S, Austin JH, Basner RC, Keller BM, Reeves AP, Shimbo D, Stevenson L. Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the Emphysema and Cancer Action Project (EMCAP) Study. Am J Respir Crit Care Med. 2007 Dec 15;176(12):1200-7. doi: 10.1164/rccm.200707-980OC. Epub 2007 Aug 29.

    PMID: 17761614RESULT

  • Varraso R, Fung TT, Barr RG, Hu FB, Willett W, Camargo CA Jr. Prospective study of dietary patterns and chronic obstructive pulmonary disease among US women. Am J Clin Nutr. 2007 Aug;86(2):488-95. doi: 10.1093/ajcn/86.2.488.

    PMID: 17684223RESULT

  • Jones DP, Camargo CA Jr, Speizer FE, Barr RG. Prospective study of short stature and newly diagnosed asthma in women. J Asthma. 2007 May;44(4):291-5. doi: 10.1080/02770900701344116.

    PMID: 17530528RESULT

  • Jiang R, Paik DC, Hankinson JL, Barr RG. Cured meat consumption, lung function, and chronic obstructive pulmonary disease among United States adults. Am J Respir Crit Care Med. 2007 Apr 15;175(8):798-804. doi: 10.1164/rccm.200607-969OC. Epub 2007 Jan 25.

    PMID: 17255565RESULT

  • Barr RG, Bourbeau J, Camargo CA, Ram FS. Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis. Thorax. 2006 Oct;61(10):854-62. doi: 10.1136/thx.2006.063271. Epub 2006 Jul 14.

    PMID: 16844726RESULT

  • Jiang R, Jacobs DR Jr, Mayer-Davis E, Szklo M, Herrington D, Jenny NS, Kronmal R, Barr RG. Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2006 Feb 1;163(3):222-31. doi: 10.1093/aje/kwj033. Epub 2005 Dec 15.

    PMID: 16357111RESULT

Related Links

MeSH Terms

Conditions

Pulmonary Disease, Chronic ObstructiveEmphysema

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • R. Graham Barr, M.D., Dr.PH.

    Columbia University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 12, 2009

First Posted

February 13, 2009

Study Start

October 1, 2004

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Last Updated

April 23, 2026

Record last verified: 2026-04