Energy Expenditure in Breast and Bottle Feeding Preterm Infants Fed Their Mother's Breast Milk

NCT00838188 | Completed

• 1 other identifier: 920060356
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 2

Brief Summary

OBJECTIVE. Neonatologists consider early feeding at the breast to be too tiring for preterm infants, although there is no evidence that this is actually the case. It is also not known whether the method of feeding affects energy expenditure. We hypothesized that resting energy expenditure (REE) would be higher after breastfeeding than after bottle feeding. PATIENTS AND METHODS. preterm ( \>32 weeks GA) stable infants who are nourished entirely by their mothers' breast milk will be studied when fed expressed breast milk either by bottle or at the breast. REE will be measured for 20 minutes after feeding. Breast milk quantity is evaluated by pre- and post feeding weighing.

Conditions

Preterm Infants

Keywords

Metabolic rate; indirect calorimetry; oral feeding

Outcome Measures

Primary Outcomes (1)

• The primary goal of this study was to compare resting energy expenditure (REE) in preterm infants who were fed their mothers' expressed milk by bottle and at the breast

  20 minutes after each meal

Secondary Outcomes (1)

• Creamatocrit of the bottle at the beginning and the completion of every feeding at the breast were measured

  Not relevant

Study Arms (5)

1

computer-generated random numbers in sealed opaque envelopes to assign the breast/bottle sequence

Other: Way of Feeding - Breast feeding vs. Bottle feeding

2

computer-generated random numbers in sealed opaque envelopes to assign the breast/bottle sequence

Other: Way of Feeding - Breast feeding vs. Bottle feeding

Breast - feeding first

computer-generated random numbers in sealed opaque envelopes to assign the breast/bottle sequence

Other: Way of Feeding - Breast feeding vs. Bottle feeding

Bottle first

computer-generated random numbers in sealed opaque envelopes to assign the breast/bottle sequence

Other: Way of Feeding - Breast feeding vs. Bottle feeding

Way of feeding

Each infant is evaluated twice, once after breastfeeding and once after bottle feeding of breast milk using a Premature Nipple \& Ring (Ross Products Division, Columbus OH, USA). In this way, each infant serves as its own control. REE is recorded for 20 minutes after each meal

Other: Way of Feeding - Breast feeding vs. Bottle feeding

Interventions

Way of Feeding - Breast feeding vs. Bottle feeding OTHER

Each infant was evaluated twice, once after breastfeeding and once after bottle feeding of breast. Computer-generated random numbers in sealed opaque envelopes to assign the breast/bottle sequence

1; 2; Bottle first; Breast - feeding first; Way of feeding

Eligibility Criteria

• Age: 34 Weeks - 40 Weeks
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Preterm infants born after 32 weeks of gestation, when they reached the corrected gestational age of 34 weeks or more.

You may qualify if:

• Thermally stable infants were nursed in an open and unwarmed bassinet.
• All fed solely by their mothers' breast milk equivalent to at least 150 cc/kg/day divided into eight meals and growing steadily

You may not qualify if:

• Infants with congenital anomalies and infants who had either more than five daily episodes of apnea of prematurity or any apnea requiring assistance or methylxanthine therapy

Sponsors & Collaborators

• Tel-Aviv Sourasky Medical Center: lead

Study Sites (2)

Department of Neonatology, Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Location

Sourasky Medical Center

Tel Aviv, Israel

Location

Related Publications (1)

• Berger I, Weintraub V, Dollberg S, Kopolovitz R, Mandel D. Energy expenditure for breastfeeding and bottle-feeding preterm infants. Pediatrics. 2009 Dec;124(6):e1149-52. doi: 10.1542/peds.2009-0165. Epub 2009 Nov 23.

  PMID: 19933725 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Maternal breast milk

Study Officials

• Irit Berger, MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: February 5, 2009
• First Posted: February 6, 2009
• Study Start: November 1, 2007
• Study Completion: March 1, 2008
• Last Updated: February 6, 2009

Record last verified: 2009-02

Locations

IL (2)