Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease

NCT00831220 | Completed

• 1 other identifier: PI04/1946
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To investigate the potential role of endothelial dysfunction as a pathogenic mechanism of cardiovascular events in COPD. Hypothesis: endothelial function is abnormal in patients with COPD, particularly during exacerbations of the disease. Design: prospective and controlled study performed in an university hospital. Population: we compare 4 groups of subjects, 44 patients with stable COPD, 35 patients with acute exacerbation of COPD, 10 smokers or former smokers with normal lung function and 10 never smokers matched by physical activity and BMI. Study variables: a) clinical variables: clinical information, physical examination, pulmonary function tests, ECG and sputum culture; b) Biological variables: number of Circulating Endothelial Progenitor Cells, vascular growth factors (vascular endothelial growht factor and erythropoietin), systemic inflammation (C-reactive protein, white blood cells), peripheral venous blood test (including hemogram, biochemical analysis with glycemia, cholesterol, LDLcol, HDLcol); and c) systemic vascular reactivity assessment.

Conditions

Chronic Obstructive Pulmonary Disease; Endothelial Dysfunction

Keywords

COPD; exacerbations; EPCs; Erythropoietin; C-RP; COPD and endothelial dysfunction

Study Arms (4)

1

Patients with a COPD exacerbation

2

Patients with stable COPD

3

Smokers or former smokers

4

Never smokers

Eligibility Criteria

• Age: 45 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with an exacerbation of COPD admitted to our hospital, stable COPD recruited in an ambulatory basis, smokers or former smokers and never smokers recruited in our laboratory.

You may qualify if:

• Patients with moderate to very severe COPD admitted in the hospital because of an exacerbation, and,
• Patients with moderate to very severe COPD in stable condition.

You may not qualify if:

• Patients with an exacerbation of COPD who needed invasive or non invasive mechanical ventilation
• Patients with other chronic inflammatory diseases.
• Patients with other acute or active chronic systemic disease such as heart failure, renal insufficiency, etc.

Sponsors & Collaborators

• Hospital Universitari Son Dureta: lead
• Fondo de Investigacion Sanitaria: collaborator

Study Sites (1)

Hospital Universitari Son Dureta

Palma Mallorca, Balearic Islands, 07014, Spain

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma and serum.

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ernest Sala, MD

  Servei de Pneumologia, Hospital Universitari Son Dureta

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 27, 2009
• First Posted: January 28, 2009
• Study Start: March 1, 2005
• Primary Completion: October 1, 2007
• Study Completion: October 1, 2007
• Last Updated: January 28, 2009

Record last verified: 2009-01

Locations

ES (1)